Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled Drug Delivery, Release, and Imaging
文献类型：期刊论文
| 作者 | Senthilkumar, Thangaraj1; Zhou, Lingyun1,2; Gu, Qi3; Liu, Libing1,2; Lv, Fengting1; Wang, Shu1,2 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 57期号:40页码:13114-13119 |
| 关键词 | Conjugated Polymer Nanoparticles Drug Delivery Imaging Photo-responsive Systems |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201807158 |
| 英文摘要 | Carriers that can afford tunable physical and structural changes are envisioned to address critical issues in controlled drug delivery applications. Herein, photo-responsive conjugated polymer nanoparticles (CPNs) functionalized with donor-acceptor Stenhouse adduct (DASA) and folic acid units for controlled drug delivery and imaging are reported. Upon visible-light (lambda=550nm) irradiation, CPNs simultaneously undergo structure, color, and polarity changes that release encapsulated drugs into the cells. The backbone of CPNs favors FRET to DASA units boosting their fluorescence. Notably, drug-loaded CPNs exhibit excellent biocompatibility in the dark, indicating perfect control of the light trigger over drug release. Delivery of both hydrophilic and hydrophobic drugs with good loading efficiency was demonstrated. This strategy enables remotely controlled drug delivery with visible-light irradiation, which sets an example for designing delivery vehicles for non-invasive therapeutics. |
| 语种 | 英语 |
| WOS记录号 | WOS:000445445700018 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42983]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Libing; Wang, Shu |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Coll Chem, Beijing 100049, Peoples R China 3.Chinese Acad Sci, State Key Lab Membrane Biol, Inst Zool, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Senthilkumar, Thangaraj,Zhou, Lingyun,Gu, Qi,et al. Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled Drug Delivery, Release, and Imaging[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(40):13114-13119. |
| APA | Senthilkumar, Thangaraj,Zhou, Lingyun,Gu, Qi,Liu, Libing,Lv, Fengting,&Wang, Shu.(2018).Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled Drug Delivery, Release, and Imaging.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(40),13114-13119. |
| MLA | Senthilkumar, Thangaraj,et al."Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled Drug Delivery, Release, and Imaging".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.40(2018):13114-13119. |
入库方式： OAI收割
来源：化学研究所
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