Development of Organic/Inorganic Compatible and Sustainably Bioactive Composites for Effective Bone Regeneration
文献类型：期刊论文
| 作者 | Shao, Nannan1,2; Guo, Jinshan3; Guan, Yuyao4; Zhang, HuanHuan1; Li, Xiaoyuan1; Chen, Xuesi5; Zhou, Dongfang1; Huang, Yubin1 |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 19期号:9页码:3637-3648 |
| ISSN号 | 1525-7797 |
| DOI | 10.1021/acs.biomac.8b00707 |
| 英文摘要 | In this paper, we demonstrate a strategy of covalently bonding bioactive molecules onto inorganic hydroxyapatite (HAp) to improve the compatibility between organic and inorganic components and endow the bone composites with sustainable bioactivity. Bone morphogenetic protein-2 (BMP-2) peptide covalently immobilized nano-hydroxyapatite (nHAp-BMP-2) is developed to preserve the bioactivity and slow the release of the BMP-2 peptide. Then nHAp-BMP-2 was further incorporated into an ultraviolet-curable mixture of gelatin methacrylamide (GelMA) and four-armed PEG methacrylamide (four-armed PEGMA) to form a Gel/(nHAp-BMP-2) composite. The hydrogen bonding between gelatin and BMP-2 on nHAp-BMP-2 enhanced the compatibility between inorganic and organic components. The Gel/(nHAp-BMP-2) composite exhibited superior biocompatibility caused by gelatin and nHAp-BMP-2, except in a two-dimensional cell culture, the hydrogel was also capable of a three-dimensional cell culture. In addition, the introduction of nHAp-BMP-2 had a positive influence on bone marrow mesenchymal stem cell proliferation, differentiation, and the subsequent calcification on the composite. After treatment of a rat calvarial defect model for 12 weeks, the Gel/(nHAp-BMP-2) group showed the largest new bone volume and the highest ratio of new bone (50.54 +/- 13.51 mm(3) and 64.38 +/- 17.22%, respectively) compared to those of the other groups. These results demonstrate that this way of controlling BMP-2 release is effective and the Gel/(nHAp-BMP-2) composite has great potential in bone regeneration therapy. |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000444527300005 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43043]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhou, Dongfang; Huang, Yubin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 3.Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA 4.Jilin Univ, China Japan Union Hosp, Dept Radiol, Changchun 130022, Jilin, Peoples R China 5.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Nannan,Guo, Jinshan,Guan, Yuyao,et al. Development of Organic/Inorganic Compatible and Sustainably Bioactive Composites for Effective Bone Regeneration[J]. BIOMACROMOLECULES,2018,19(9):3637-3648. |
| APA | Shao, Nannan.,Guo, Jinshan.,Guan, Yuyao.,Zhang, HuanHuan.,Li, Xiaoyuan.,...&Huang, Yubin.(2018).Development of Organic/Inorganic Compatible and Sustainably Bioactive Composites for Effective Bone Regeneration.BIOMACROMOLECULES,19(9),3637-3648. |
| MLA | Shao, Nannan,et al."Development of Organic/Inorganic Compatible and Sustainably Bioactive Composites for Effective Bone Regeneration".BIOMACROMOLECULES 19.9(2018):3637-3648. |
入库方式： OAI收割
来源：化学研究所
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