Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery
文献类型：期刊论文
| 作者 | Wang, Lin1,2; Shi, Xuefeng1; Zhang, Jian3; Zhu, Yuejun3; Wang, Jinben1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:55页码:31581-31587 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c8ra06064a |
| 英文摘要 | In this study, a novel supramolecular hydrogel system, abbreviated as AGC(16)/NTS, prepared by molecular self-assembly of cationic gemini surfactant 1,3-bis(N,N-dimethyl-N-cetylammonium)-2-propylacrylatedibromide (AGC(16)) and anionic aromatic compound trisodium 1,3,6-naphthalenetrisulfonate (NTS), was used to encapsulate hydrophobic model drug curcumin (Cur), constructing a pH-responsive drug delivery system. Cur was effectively encapsulated into the hydrophobic domains of AGC(16)/NTS through hydrophobic interaction, which was confirmed by H-1 NMR measurement. The effects of Cur on the mechanical strength, phase transition behaviour and morphology of AGC(16)/NTS were characterized by rheology and cryogenic scanning electron microscopy (cryo-SEM) methods. The pH-responsive release of Cur from AGC(16)/NTS was obtained and the release amount of Cur ascended with pH value decreasing from 7.4 to 3.0. The hydrodynamic sizes of the released Cur-aggregates determined by dynamic light scattering (DLS) were used to analyse the release process of Cur at different pH. The cell viability assay and cell imaging experiment demonstrated that Cur-loaded hydrogel has much higher cytotoxicity and better cell uptake compared to free Cur. Overall, the AGC(16)/NTS hydrogel is a prospective material for use in encapsulation and controlled-release of hydrophobic drug molecules. |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000445221300040 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43045]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shi, Xuefeng; Wang, Jinben |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.CNOOC Res Inst Co Ltd, State Key Lab Offshore Oil Exploitat, Beijing 100028, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lin,Shi, Xuefeng,Zhang, Jian,et al. Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery[J]. RSC ADVANCES,2018,8(55):31581-31587. |
| APA | Wang, Lin,Shi, Xuefeng,Zhang, Jian,Zhu, Yuejun,&Wang, Jinben.(2018).Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery.RSC ADVANCES,8(55),31581-31587. |
| MLA | Wang, Lin,et al."Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery".RSC ADVANCES 8.55(2018):31581-31587. |
入库方式： OAI收割
来源：化学研究所
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