Rationally Designed Fluorescence (OH)-O-center dot Probe with High Sensitivity and Selectivity for Monitoring the Generation of (OH)-O-center dot in Iron Autoxidation without Addition of H2O2
文献类型：期刊论文
| 作者 | Li, Hongyu1,2; Li, Xiaohua1; Shi, Wen1; Xu, Yanhui1; Ma, Huimin1,2 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2018-09-24 |
| 卷号 | 57期号:39页码:12830-12834 |
| 关键词 | Analytical Methods Fluorescent Probes Hydroxyl Radicals Iron Autoxidation |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201808400 |
| 英文摘要 | The first sensitive fluorescence (OH)-O-center dot probe (1) that is capable of monitoring the generation of trace (OH)-O-center dot in iron autoxidation is presented. The probe 1 was designed by utilizing both the unique aromatic hydroxylation and the electrophilicity of (OH)-O-center dot, and prepared by incorporating a strong electron-donating methoxy group into a cyanine fluorochrome to enhance the trapping ability for (OH)-O-center dot. Reaction of 1 with (OH)-O-center dot leads to a larger pi-conjugation formation and near-infrared fluorescence off-on response. The capability of probe 1 has been demonstrated by imaging (OH)-O-center dot generated in living cells under iron autoxidation as well as various stimuli, which reveals that the basal level of (OH)-O-center dot in RAW 264.7 cells is lower than that in HeLa cells. The superior analytical performance of probe 1 makes it useful for detecting trace (OH)-O-center dot in some critical physiological and pathological processes associated with iron autoxidation. |
| 语种 | 英语 |
| WOS记录号 | WOS:000444941600039 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43067]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Xiaohua; Shi, Wen; Ma, Huimin |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hongyu,Li, Xiaohua,Shi, Wen,et al. Rationally Designed Fluorescence (OH)-O-center dot Probe with High Sensitivity and Selectivity for Monitoring the Generation of (OH)-O-center dot in Iron Autoxidation without Addition of H2O2[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(39):12830-12834. |
| APA | Li, Hongyu,Li, Xiaohua,Shi, Wen,Xu, Yanhui,&Ma, Huimin.(2018).Rationally Designed Fluorescence (OH)-O-center dot Probe with High Sensitivity and Selectivity for Monitoring the Generation of (OH)-O-center dot in Iron Autoxidation without Addition of H2O2.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(39),12830-12834. |
| MLA | Li, Hongyu,et al."Rationally Designed Fluorescence (OH)-O-center dot Probe with High Sensitivity and Selectivity for Monitoring the Generation of (OH)-O-center dot in Iron Autoxidation without Addition of H2O2".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.39(2018):12830-12834. |
入库方式： OAI收割
来源：化学研究所
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