Sepatation of Antipyretic Analgesics by Capillary Electrochromatography with Block Copolymer Coating
文献类型：期刊论文
| 作者 | Feng Wenya1,2; Qiao Juan2,3; Qi Li2,3; Li Zhiwei1 |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2018-08-10 |
| 卷号 | 39期号:8页码:1640-1646 |
| 关键词 | Open Tubular Capillary Electrochromatography Block Copolymer Coating Antipyretic Analgesics |
| ISSN号 | 0251-0790 |
| DOI | 10.7503/cjcu20170853 |
| 英文摘要 | A unique open tubular capillary electrochromatography (OT-CEC) system with block copolymer coating was constructed for separation of antipyretic analgesics. The amphipathic poly (maleic anhydride-costyrene) was synthesized by reversible addition-fragmentation chain transfer polymerization method. The effects of several key factors on the OT-CEC separation efficiency were investigated. Interestingly, by adding organic solvent to the running buffer, the block copolymer coating could self-assemble to form micelle-like spheres and play the role of surfactants. Comparing with the bare capillary, the coating one could enhance the separation efficiency obviously. Moreover, the results indicated that the coating capillaries had a good stability and repeatability. Under the optimized OT-CEC conditions, the developed OT-CEC assay was used to ananlyze the antipyretic drugs in clinical tables with satisfactory linearity (R-2 >= 0.988). The detection limits obtained from the calculations based on signal-to-noise ratio( S/N = 3) were 3.5-4.8 mu g/mL for the test drugs. |
| 语种 | 英语 |
| WOS记录号 | WOS:000440135100004 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43081]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qi Li; Li Zhiwei |
| 作者单位 | 1.Heibei Univ Sci & Technol, Coll Chem & Pharmaceut, Shijiazhuang 050018, Hebei, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng Wenya,Qiao Juan,Qi Li,et al. Sepatation of Antipyretic Analgesics by Capillary Electrochromatography with Block Copolymer Coating[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2018,39(8):1640-1646. |
| APA | Feng Wenya,Qiao Juan,Qi Li,&Li Zhiwei.(2018).Sepatation of Antipyretic Analgesics by Capillary Electrochromatography with Block Copolymer Coating.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,39(8),1640-1646. |
| MLA | Feng Wenya,et al."Sepatation of Antipyretic Analgesics by Capillary Electrochromatography with Block Copolymer Coating".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 39.8(2018):1640-1646. |
入库方式： OAI收割
来源：化学研究所
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