Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents
文献类型：期刊论文
| 作者 | McHugh, Kevin J.1; Jing, Lihong1,2; Behrens, Adam M.1; Jayawardena, Surangi1; Tang, Wen1; Gao, Mingyuan2; Langer, Robert1; Jaklenec, Ana1 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2018-05-03 |
| 卷号 | 30期号:18 |
| 关键词 | Cancer Imaging Fluorescence Near-infrared Optical Imaging Quantum Dots |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201706356 |
| 英文摘要 | Approximately 1.7 million new cases of cancer will be diagnosed this year in the United States leading to 600 000 deaths. Patient survival rates are highly correlated with the stage of cancer diagnosis, with localized and regional remission rates that are much higher than for metastatic cancer. The current standard of care for many solid tumors includes imaging and biopsy with histological assessment. In many cases, after tomographical imaging modalities have identified abnormal morphology consistent with cancer, surgery is performed to remove the primary tumor and evaluate the surrounding lymph nodes. Accurate identification of tumor margins and staging are critical for selecting optimal treatments to minimize recurrence. Visible, fluorescent, and radiolabeled small molecules have been used as contrast agents to improve detection during real-time intraoperative imaging. Unfortunately, current dyes lack the tissue specificity, stability, and signal penetration needed for optimal performance. Quantum dots (QDs) represent an exciting class of fluorescent probes for optical imaging with tunable optical properties, high stability, and the ability to target tumors or lymph nodes based on surface functionalization. Here, state-of-the-art biocompatible QDs are compared with current Food and Drug Administration approved fluorophores used in cancer imaging and a perspective on the pathway to clinical translation is provided. |
| 语种 | 英语 |
| WOS记录号 | WOS:000431615100013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43111]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Langer, Robert; Jaklenec, Ana |
| 作者单位 | 1.MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA 2.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | McHugh, Kevin J.,Jing, Lihong,Behrens, Adam M.,et al. Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents[J]. ADVANCED MATERIALS,2018,30(18). |
| APA | McHugh, Kevin J..,Jing, Lihong.,Behrens, Adam M..,Jayawardena, Surangi.,Tang, Wen.,...&Jaklenec, Ana.(2018).Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents.ADVANCED MATERIALS,30(18). |
| MLA | McHugh, Kevin J.,et al."Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents".ADVANCED MATERIALS 30.18(2018). |
入库方式： OAI收割
来源：化学研究所
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