Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering
文献类型：期刊论文
| 作者 | Shi, Xu-Dong1,2; Sun, Pei-Jian2; Gan, Zhi-Hua2,3 |
| 刊名 | CHINESE JOURNAL OF POLYMER SCIENCE
 |
| 出版日期 | 2018-06-01 |
| 卷号 | 36期号:6页码:712-719 |
| 关键词 | Polylactide Porous Microspheres Drug Release Cell Tissue Engineering |
| ISSN号 | 0256-7679 |
| DOI | 10.1007/s10118-018-2079-x |
| 英文摘要 | In this study, porous polylactide (PLA) microspheres with different structures were prepared through the multiple emulsion solvent evaporation method. By changing organic solvents (ethyl acetate and chloroform) and adding effervescent salt NH4HCO3 in the inner water phase, microspheres with porous capsular, matrix, microcapsular and multivesicular structures were prepared. The protein encapsulation and release, and the cell growth behavior of porous microspheres were further explored. Under the same inner water phase, microspheres prepared with chloroform had higher protein encapsulation efficiency and less protein release rate as compared with those prepared with ethyl acetate. Cell experiments showed that the relatively rough surface of microspheres prepared with chloroform was more favorable for the cell growth in comparison with the smooth surface of microspheres prepared with ethyl acetate. This study shows a simple and effective method to control the protein release and cell growth behaviors of polymer microspheres by tuning their porous structure. |
| 语种 | 英语 |
| WOS记录号 | WOS:000431664900004 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43147]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Gan, Zhi-Hua |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 3.Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Xu-Dong,Sun, Pei-Jian,Gan, Zhi-Hua. Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2018,36(6):712-719. |
| APA | Shi, Xu-Dong,Sun, Pei-Jian,&Gan, Zhi-Hua.(2018).Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering.CHINESE JOURNAL OF POLYMER SCIENCE,36(6),712-719. |
| MLA | Shi, Xu-Dong,et al."Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering".CHINESE JOURNAL OF POLYMER SCIENCE 36.6(2018):712-719. |
入库方式： OAI收割
来源：化学研究所
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