Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity
文献类型：期刊论文
| 作者 | Li, Yawei1,4; Liu, Wensen1; Sun, Chengbiao1; Zheng, Min2; Zhang, Jianxu3; Liu, Bin1; Wang, Yan1; Xie, Zhigang3; Xu, Na1,4 |
| 刊名 | JOURNAL OF COLLOID AND INTERFACE SCIENCE
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 523页码:226-233 |
| 关键词 | Rtb Carbon Dots Nanoparticle Macrophage Immunomodulatory Activity |
| ISSN号 | 0021-9797 |
| DOI | 10.1016/j.jcis.2018.03.108 |
| 英文摘要 | Although Ricin toxin binding subunit B (RTB) can promote the activation of macrophages and modulate the cell-mediated immunity, its applications are severely limited due to the intrinsic properties of proteins, like poor stability and low efficacy of cellular uptake. In this work, the stable nanoparticles were prepared by supramolecular assembling of carbon dots (CDs) and RTB. The formed CDs-RTB possesses robust stability and can protect RTB against enzymatic hydrolysis More importantly, CDs-RTB can promote macrophages proliferation, improve the generation of NO, 1L-6 and TNF-a in RAW264.7 cells and increase the expression of mRNA, indicating the enhanced immunomodulatory activity of CDs-RTB. This work highlights the potential of using CDs as a simple and stable platform to assemble RTB and effectively promotes the application of RTB as the lmmunostimulant. (C) 2018 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000431745500024 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43185]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zheng, Min; Xu, Na |
| 作者单位 | 1.Acad Mil Med Sci, Inst Mil Vet Med, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Jilin, Peoples R China 2.Changchun Univ Technol, Chem & Life Sci Sch, Adv Inst Mat Sci, 2055 Yanan St, Changchun 130012, Jilin, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 4.Jilin Med Univ, Changchun 132013, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yawei,Liu, Wensen,Sun, Chengbiao,et al. Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2018,523:226-233. |
| APA | Li, Yawei.,Liu, Wensen.,Sun, Chengbiao.,Zheng, Min.,Zhang, Jianxu.,...&Xu, Na.(2018).Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity.JOURNAL OF COLLOID AND INTERFACE SCIENCE,523,226-233. |
| MLA | Li, Yawei,et al."Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity".JOURNAL OF COLLOID AND INTERFACE SCIENCE 523(2018):226-233. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。