Highly luminescent, biocompatible ytterbium(III) complexes as near-infrared fluorophores for living cell imaging
文献类型：期刊论文
| 作者 | Ning, Yingying1; Tang, Juan1; Liu, Yi-Wei1; Jing, Jing2; Sun, Yuansheng3; Zhang, Jun-Long1 |
| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2018-04-21 |
| 卷号 | 9期号:15页码:3742-3753 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/c8sc00259b |
| 英文摘要 | Herein, we report the design and synthesis of biocompatible Yb3+ complexes for near-infrared (NIR) living cell imaging. Upon excitation at either the visible (Soret band) or red region (Q band), these beta-fluorinated Yb3+ complexes display high NIR luminescence (quantum yields up to 23% and 13% in dimethyl sulfoxide and water, respectively) and have higher stabilities and prolonged decay lifetimes (up to 249 mu s) compared to the beta-non-fluorinated counterparts. This renders the beta-fluorinated Yb3+ complexes as a new class of biological optical probes in both steady-state imaging and time-resolved fluorescence lifetime imaging (FLIM). NIR confocal fluorescence images showed strong and specific intracellular Yb3+ luminescence signals when the biocompatible Yb3+ complexes were uptaken into the living cells. Importantly, FLIM measurements showed an intracellular lifetime distribution between 100 and 200 ms, allowing an effective discrimination from cell autofluorescence, and afforded high signal-to-noise ratios as firstly demonstrated in the NIR region. These results demonstrated the prospects of NIR lanthanide complexes as biological probes for NIR steady-state fluorescence and time-resolved fluorescence lifetime imaging. |
| 语种 | 英语 |
| WOS记录号 | WOS:000431389300015 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43203]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Jing; Zhang, Jun-Long |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Beijing Inst Technol, Sch Chem, Beijing 100081, Peoples R China 3.ISS Inc, Champaign, IL 61822 USA |
| 推荐引用方式 GB/T 7714 | Ning, Yingying,Tang, Juan,Liu, Yi-Wei,et al. Highly luminescent, biocompatible ytterbium(III) complexes as near-infrared fluorophores for living cell imaging[J]. CHEMICAL SCIENCE,2018,9(15):3742-3753. |
| APA | Ning, Yingying,Tang, Juan,Liu, Yi-Wei,Jing, Jing,Sun, Yuansheng,&Zhang, Jun-Long.(2018).Highly luminescent, biocompatible ytterbium(III) complexes as near-infrared fluorophores for living cell imaging.CHEMICAL SCIENCE,9(15),3742-3753. |
| MLA | Ning, Yingying,et al."Highly luminescent, biocompatible ytterbium(III) complexes as near-infrared fluorophores for living cell imaging".CHEMICAL SCIENCE 9.15(2018):3742-3753. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。