Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy
文献类型：期刊论文
| 作者 | Lian, Xizhen1; Huang, Yanyan2,3; Zhu, Yuanyuan2,3; Fang, Yu1; Zhao, Rui2,3; Joseph, Elizabeth1; Li, Jialuo1; Pellois, Jean-Philippe1,4; Zhou, Hong-Cai1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2018-05-14 |
| 卷号 | 57期号:20页码:5725-5730 |
| ISSN号 | 1433-7851 |
| 关键词 | Cancer Drug Delivery Enzymes Metal-organic Frameworks Nanoparticles |
| DOI | 10.1002/anie.201801378 |
| 英文摘要 | Prodrug activation, by exogenously administered enzymes, for cancer therapy is an approach to achieve better selectivity and less systemic toxicity than conventional chemotherapy. However, the short half-lives of the activating enzymes in the bloodstream has limited its success. Demonstrated here is that a tyrosinase-MOF nanoreactor activates the prodrug paracetamol in cancer cells in a long-lasting manner. By generating reactive oxygen species (ROS) and depleting glutathione (GSH), the product of the enzymatic conversion of paracetamol is toxic to drug-resistant cancer cells. Tyrosinase-MOF nanoreactors cause significant cell death in the presence of paracetamol for up to three days after being internalized by cells, while free enzymes totally lose activity in a few hours. Thus, enzyme-MOF nanocomposites are envisioned to be novel persistent platforms for various biomedical applications. |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000431488200024 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43283]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhou, Hong-Cai |
| 作者单位 | 1.Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 4.Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA |
| 推荐引用方式 GB/T 7714 | Lian, Xizhen,Huang, Yanyan,Zhu, Yuanyuan,et al. Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(20):5725-5730. |
| APA | Lian, Xizhen.,Huang, Yanyan.,Zhu, Yuanyuan.,Fang, Yu.,Zhao, Rui.,...&Zhou, Hong-Cai.(2018).Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(20),5725-5730. |
| MLA | Lian, Xizhen,et al."Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.20(2018):5725-5730. |
入库方式： OAI收割
来源：化学研究所
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