A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein
文献类型：期刊论文
| 作者 | Du, Jun1; Wei, Yuanyuan1,2; Zhao, Yao2; Xu, Fengmin1,2; Wang, Yuanyuan2,3; Zheng, Wei2; Luo, Qun2,3; Wang, Ming2,3; Wang, Fuyi2,3 |
| 刊名 | INORGANIC CHEMISTRY
 |
| 出版日期 | 2018-05-07 |
| 卷号 | 57期号:9页码:5575-5584 |
| ISSN号 | 0020-1669 |
| DOI | 10.1021/acs.inorgchem.8b00529 |
| 英文摘要 | Thioredoxin (Trx) is an important enzyme in the redox signaling pathway and is usually overexpressed in tumor cells. We demonstrate herein that the photoactive platinum (IV) anticancer complex tra ns,trans, trans-[Pt(N-3)(2),(OH)(2)(Py)(2)] (1) can bind to His, Glu, and Gln residues of Trx upon the irradiation of blue light. More importantly, complex 1 can also induce the oxidation of Met, Trp, and the Cys catalytic sites to form disulfide bonds by generating reactive oxygen species (ROS) upon photoactivation. These eventually lead to inhibition of activity of Trx enzyme and the Trx system and further increase in the cellular ROS level. We speculate that the oxidative damage not only inhibits Trx activity but also greatly contributes to the anticancer action of complex 1. |
| 语种 | 英语 |
| WOS记录号 | WOS:000431833500089 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43287]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, Yao; Wang, Fuyi |
| 作者单位 | 1.Anhui Normal Univ, Anhui Lab Mol Based Mat, Coll Chem & Mat Sci, Key Lab Funct Mol Solids,Minist Educ, Wuhu 241000, Peoples R China 2.Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Natl Ctr Mass Spectrometry Beijing,Beijing Natl L, CAS Key Lab Analyt Chem Living Biosyst,Inst Chem, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Jun,Wei, Yuanyuan,Zhao, Yao,et al. A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein[J]. INORGANIC CHEMISTRY,2018,57(9):5575-5584. |
| APA | Du, Jun.,Wei, Yuanyuan.,Zhao, Yao.,Xu, Fengmin.,Wang, Yuanyuan.,...&Wang, Fuyi.(2018).A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein.INORGANIC CHEMISTRY,57(9),5575-5584. |
| MLA | Du, Jun,et al."A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein".INORGANIC CHEMISTRY 57.9(2018):5575-5584. |
入库方式： OAI收割
来源：化学研究所
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