Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands
文献类型：期刊论文
| 作者 | Gai Wei1,2; Yang QianFan1; Xiang JunFeng1; Sun HongXia1,2; Shang Qian1; Li Qian1; Jiang Wei1; Guan AiJiao1,2; Zhang Hong1; Tang YaLin1 |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2013-03-01 |
| 卷号 | 58期号:7页码:731-740 |
| 关键词 | G-quadruplex Flanking Sequences Interaction Mechanism C-myc Cyanine Dye |
| ISSN号 | 1001-6538 |
| DOI | 10.1007/s11434-012-5639-4 |
| 英文摘要 | G-quadruplexes attract more and more attention in recent years. Numerous small molecules which can induce or stabilize the formation of G-quadruplexes have been investigated on the purpose of anticancer drug development. As a motif existed in physiological condition, flanking sequences are an important part of G-quadruplexes but the study on the impact of flanking sequences on (G-quadruplex)-ligand binding is rarely reported. In this paper, the effects of flanking sequences on binding affinity between a series of unimolecular parallel-stranded G-quadruplex sequences derived from c-myc oncogene promoter (termed as c-myc G-quadruplexes) and their ligands are discussed in detail. The results showed that the flanking sequences on c-myc G-quadruplexes play key roles in (G-quadruplex)-ligand interaction. When a c-myc G-quadruplex is bound to its ligands, the flanking sequences might form a binding cavity above the terminal G-quartet, which could provide a suitable site for ligands to dock in. Moreover, the bases on flanking sequences could interact with ligand through pi-pi stacking, and finally form a sandwich-stacking mode (terminal G-quartet, ligand and bases on the flanking sequence). This mode could stabilize the (G-quadruplex)-ligand complex effectively and enhance the binding affinity dramatically. However, flanking sequences are also found to exhibit steric hindrance effect which could impede the (G-quadruplex)-ligand binding. |
| 语种 | 英语 |
| WOS记录号 | WOS:000315446200006 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43321]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang QianFan |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gai Wei,Yang QianFan,Xiang JunFeng,et al. Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands[J]. CHINESE SCIENCE BULLETIN,2013,58(7):731-740. |
| APA | Gai Wei.,Yang QianFan.,Xiang JunFeng.,Sun HongXia.,Shang Qian.,...&Xu GuangZhi.(2013).Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands.CHINESE SCIENCE BULLETIN,58(7),731-740. |
| MLA | Gai Wei,et al."Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands".CHINESE SCIENCE BULLETIN 58.7(2013):731-740. |
入库方式： OAI收割
来源：化学研究所
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