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Interaction between PEO-PPO-PEO Copolymers and a Hexapeptide in Aqueous Solutions

文献类型：期刊论文

作者Jia, Lianwei1,2; Guo, Chen1; Xiang, Junfeng3; Wang, Ning1,2; Yang, Liangrong1; Tang, Yalin3; Liu, Huizhou1
刊名LANGMUIR
出版日期2012-01-24
卷号28期号:3页码:1725-1732
ISSN号0743-7463
DOI10.1021/la203693c
英文摘要Interaction between PEO-PPO-PEO copolymers and a hexapeptide, growth hormone releasing peptide-6 (GHRP-6), was investigated by NMR to study the potential use of the copolymers in peptide drug delivery. H-1 NMR and nuclear Overhauser effect spectroscopy (NOESY) measurements determined that PO methyl protons interacted with methyl protons of the Ala moiety, aromatic protons of the Tip moiety, and some of the Phe aromatic protons. The Lys moiety and part of the Phe moiety entered the hydrophilic EO environment via hydrogen bonding. PEO PPO PEO copolymers and the peptide formed a complex in 1:1 stoichiometry. Binding constants between copolymers and GHRP-6 were determined, and it was indicated that the copolymers containing more EO and PO units will lead to greater affinity with the peptide. Isothermal titration calorimetry (ITC) measurements confirmed the results of NMR experiments. This study indicates that PEO-PPO-PEO copolymers have great potential in delivering peptide drugs.
语种英语
WOS记录号WOS:000299366500010
出版者AMER CHEMICAL SOC
源URL[http://ir.iccas.ac.cn/handle/121111/43429]  
专题中国科学院化学研究所
通讯作者Guo, Chen
作者单位1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Ctr Mol Sci,Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Jia, Lianwei,Guo, Chen,Xiang, Junfeng,et al. Interaction between PEO-PPO-PEO Copolymers and a Hexapeptide in Aqueous Solutions[J]. LANGMUIR,2012,28(3):1725-1732.
APA Jia, Lianwei.,Guo, Chen.,Xiang, Junfeng.,Wang, Ning.,Yang, Liangrong.,...&Liu, Huizhou.(2012).Interaction between PEO-PPO-PEO Copolymers and a Hexapeptide in Aqueous Solutions.LANGMUIR,28(3),1725-1732.
MLA Jia, Lianwei,et al."Interaction between PEO-PPO-PEO Copolymers and a Hexapeptide in Aqueous Solutions".LANGMUIR 28.3(2012):1725-1732.

入库方式： OAI收割

来源：化学研究所

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