Self-immolative nanoparticles triggered by hydrogen peroxide and pH
文献类型：期刊论文
| 作者 | Wang, Zhijian; Sun, Jianbo; Jia, Xinru |
| 刊名 | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
 |
| 出版日期 | 2014-07-15 |
| 卷号 | 52期号:14页码:1962-1969 |
| 关键词 | Nanoparticles Oligomers Step-growth Polymerization Stimuli-sensitive Polymers |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.27203 |
| 英文摘要 | The azomethine-based oligomers bearing boronate groups and imine moieties in the main chain were synthesized from a dialdehyde monomer and an aromatic (oligomer 4) diamine or an aliphatic diamine (oligomer 5). Based on the oligomers, the nanoparticles with hydrogen peroxide (H2O2) and pH dual-responsive properties were constructed and encapsulated nile red inside. The nanoparticles disassembled either by the trigger of H2O2 or by the attack of H+, thus leading to the release of loaded species. Compared to oligomer 4, oligomer 5 showed a faster degradation rate in the presence of H2O2, especially in a weak acidic environment. No significant cytotoxicity was observed as HeLa cells incubated in the nanoparticles with the concentration up to 200 g/mL evidenced by cytotoxicity assay in vitro. Such a system capable of dual response of H2O2 and H+ may have potential application as a carrier for drug delivery. (c) 2014 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000337682100005 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43459]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jia, Xinru |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhijian,Sun, Jianbo,Jia, Xinru. Self-immolative nanoparticles triggered by hydrogen peroxide and pH[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2014,52(14):1962-1969. |
| APA | Wang, Zhijian,Sun, Jianbo,&Jia, Xinru.(2014).Self-immolative nanoparticles triggered by hydrogen peroxide and pH.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,52(14),1962-1969. |
| MLA | Wang, Zhijian,et al."Self-immolative nanoparticles triggered by hydrogen peroxide and pH".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 52.14(2014):1962-1969. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。