SYNTHESIS OF NEW AMINO-ACID AND PEPTIDE DERIVATIVES OF ESTRADIOL AND THEIR BINDING AFFINITIES FOR THE ESTROGEN-RECEPTOR
文献类型：期刊论文
| 作者 | YE, YH; HUANG, YS; WANG, ZQ; CHEN, SM; TIAN, Y |
| 刊名 | STEROIDS
 |
| 出版日期 | 1993 |
| 卷号 | 58期号:1页码:35-39 |
| 关键词 | 17-beta-aminoestradiol Derivatives 17-hydrazonoestrone Derivatives Amino Acids Peptides Binding Affinity Estrogen Receptor Steroids |
| ISSN号 | 0039-128X |
| 英文摘要 | A series of amino acid and peptide derivatives of estradiol have been synthesized by coupling 17beta-aminoestra-1,3,5(10)-trien-3-ol, 17-hydrazonoestra-1,3,5(10)-trien-3-ol with amino acids or peptides, using tetrahydrothiazole-2-thione, N-hydroxy-1,4-epoxycyclohex-5-ene-2,3-dicarbonylimide, benzotriazolyloxy-tris(dimethylamino)phosphonium hexafluorophosphate, and p-nitrophenol as reagents. N-protected peptidyl steroids were deprotected by traditional methods. The relative binding affinities of the deprotected derivatives to the estrogen receptor were determined by competitive radioligand binding assay. |
| 语种 | 英语 |
| WOS记录号 | WOS:A1993KM95500005 |
| 出版者 | BUTTERWORTH-HEINEMANN |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/43655]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | YE, YH |
| 作者单位 | 1.ACAD MILITARY MED SCI,INST RADIAT MED,BEIJING,PEOPLES R CHINA 2.ACAD MILITARY MED SCI,INST BASIC MED SCI,BEIJING,PEOPLES R CHINA 3.CHINESE ACAD SCI,INST CHEM,BEIJING,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | YE, YH,HUANG, YS,WANG, ZQ,et al. SYNTHESIS OF NEW AMINO-ACID AND PEPTIDE DERIVATIVES OF ESTRADIOL AND THEIR BINDING AFFINITIES FOR THE ESTROGEN-RECEPTOR[J]. STEROIDS,1993,58(1):35-39. |
| APA | YE, YH,HUANG, YS,WANG, ZQ,CHEN, SM,&TIAN, Y.(1993).SYNTHESIS OF NEW AMINO-ACID AND PEPTIDE DERIVATIVES OF ESTRADIOL AND THEIR BINDING AFFINITIES FOR THE ESTROGEN-RECEPTOR.STEROIDS,58(1),35-39. |
| MLA | YE, YH,et al."SYNTHESIS OF NEW AMINO-ACID AND PEPTIDE DERIVATIVES OF ESTRADIOL AND THEIR BINDING AFFINITIES FOR THE ESTROGEN-RECEPTOR".STEROIDS 58.1(1993):35-39. |
入库方式： OAI收割
来源：化学研究所
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