PROTECTION BY SALVIANOLIC ACID-A AGAINST ADRIAMYCIN TOXICITY ON RAT-HEART MITOCHONDRIA
文献类型：期刊论文
| 作者 | LIN, TJ; LIU, GT; LIU, Y; XU, GZ |
| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
 |
| 出版日期 | 1992 |
| 卷号 | 12期号:5页码:347-351 |
| 关键词 | Adriamycin Free Radical Mitochondria Salvianolic Acid-a Lipid Peroxidation |
| ISSN号 | 0891-5849 |
| 英文摘要 | It was found that salvianolic acid A (Sai A) has potent antioxidant activity. The effects of Sai A on adriamycin-induced heart mitochondrial toxicity of rats in vitro and on adriamycin antitumor activity are investigated in this article. Malondialdehyde (MDA) formation and membrane rigidification of rat heart mitochondria intoxicated with adriamycin were significantly reduced by Sai A. In the electron spin resonance (ESR) studies. Sai A has no significant effect on the formation of adriamycin semiquinone radicals (AQ), while hydroxyl radicals generated by electron transfer from AQ. to H2O2 were scavenged by Sai A dose-dependently. On the other hand. Sai A was shown to have no effects on the antitumor activity of adriamycin in cultured L1210 ascitic tumor cells and in mice with P388 ascite tumor. These results indicate that Sai A protects against adriamycin induced heart mitochondrial toxicity of rats, while Sai A has no antagonizing effect on the antitumor activity of adriamycin. |
| 语种 | 英语 |
| WOS记录号 | WOS:A1992HQ85000002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/44279]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | 1.CHINESE ACAD MED SCI,INST MAT MED,BEIJING,PEOPLES R CHINA 2.CHINESE ACAD SCI,INST CHEM,BEIJING 100080,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | LIN, TJ,LIU, GT,LIU, Y,et al. PROTECTION BY SALVIANOLIC ACID-A AGAINST ADRIAMYCIN TOXICITY ON RAT-HEART MITOCHONDRIA[J]. FREE RADICAL BIOLOGY AND MEDICINE,1992,12(5):347-351. |
| APA | LIN, TJ,LIU, GT,LIU, Y,&XU, GZ.(1992).PROTECTION BY SALVIANOLIC ACID-A AGAINST ADRIAMYCIN TOXICITY ON RAT-HEART MITOCHONDRIA.FREE RADICAL BIOLOGY AND MEDICINE,12(5),347-351. |
| MLA | LIN, TJ,et al."PROTECTION BY SALVIANOLIC ACID-A AGAINST ADRIAMYCIN TOXICITY ON RAT-HEART MITOCHONDRIA".FREE RADICAL BIOLOGY AND MEDICINE 12.5(1992):347-351. |
入库方式： OAI收割
来源：化学研究所
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