Polycaprolactone-poly(ethylene-glycol) block copolymer .4. Biodegradation behavior in vitro and in vivo
文献类型：期刊论文
| 作者 | Bei, JZ; Li, JM; Wang, ZF; Le, JC; Wang, SG |
| 刊名 | POLYMERS FOR ADVANCED TECHNOLOGIES
 |
| 出版日期 | 1997-11-01 |
| 卷号 | 8期号:11页码:693-696 |
| ISSN号 | 1042-7147 |
| 关键词 | In Vitro In Vivo Implanting Test Polycaprolactone-poly(Ethylene Glycol) Block Copolymer Biodegradability |
| 英文摘要 | The biodegration behavior of polycaprolactone-poly(ethylene glycol) block copolymer (PCL-b-PEG) was identified by degradation tests in vitro and in vivo. The tests in vitro and in vivo were carried out by immersing samples in pH 5.0, 7.2 and 9.0 buffer solutions with or without lipase at 25.0, 37.0 and 50.0 +/- degrees C, and implanting samples in the back or small intestine of rats. It was found that the degradation rate of the PCL-b-PEG was increased with increasing PEG content, temperature, acidity or alkalinity, and it was accelerated by the presence of enzyme. The fastest degradation rate was observed in the physiological condition of the sample being implanted in the body of animals. It has been shown that the PCL-b-PEG copolymer is a possible biodegradable polymer. (C) 1997 by John Wiley & Sons, Ltd. |
| 语种 | 英语 |
| 出版者 | JOHN WILEY & SONS LTD |
| WOS记录号 | WOS:A1997YK20100014 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/44723]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | 1.CHINESE ACAD SCI,INST CHEM,BEIJING 100080,PEOPLES R CHINA 2.HENAN PROV PEOPLES HOSP,ZHENGZHOU 450003,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Bei, JZ,Li, JM,Wang, ZF,et al. Polycaprolactone-poly(ethylene-glycol) block copolymer .4. Biodegradation behavior in vitro and in vivo[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,1997,8(11):693-696. |
| APA | Bei, JZ,Li, JM,Wang, ZF,Le, JC,&Wang, SG.(1997).Polycaprolactone-poly(ethylene-glycol) block copolymer .4. Biodegradation behavior in vitro and in vivo.POLYMERS FOR ADVANCED TECHNOLOGIES,8(11),693-696. |
| MLA | Bei, JZ,et al."Polycaprolactone-poly(ethylene-glycol) block copolymer .4. Biodegradation behavior in vitro and in vivo".POLYMERS FOR ADVANCED TECHNOLOGIES 8.11(1997):693-696. |
入库方式： OAI收割
来源：化学研究所
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