Computational analysis of triplex formation of oligonucleotides: Protonated and 5-methylated py-pu-py motif
文献类型：期刊论文
| 作者 | Lee, I; Bai, CL; Wang, C; Wang, XW |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 1997-04-01 |
| 卷号 | 40期号:2页码:113-121 |
| 关键词 | Triplex Dna Computational Analysis Stability Screening Effect |
| ISSN号 | 1001-652X |
| 英文摘要 | A triple helix composed of three dodecanucleotides, 5'-d(TC)(6), 5'-(AG)(6) and 3'-d(TC)(6) with each containing a methylcytosine or a protonated-cytosine, was examined in terms of various interactions. Computational analysis of the stability of tripler formation was consistent with the experimental observations. The Hoogsteen base pairing interaction was increased through substitution of 5-methylcytosine for cytosine and/or protonation. The interaction between water molecules and DNA tripler was visualized in terms of the end-to-end distance change of each strand. The chain length was reduced by about 7.5%-16.2% due to the screening effect. In addition, as the screening effect increases, Hoogsteen base pairs appear to bd stable in tripler formation. Our computational results also show that the effect of protonated- and methylated-cytosine on the stability of tripler formation was due to the change of the electrostatic interactions rather than the surface stacking interaction. |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997WN35700001 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/44797]  |
| 专题 | 中国科学院化学研究所 |
| 作者单位 | CHINESE ACAD SCI,INST CHEM,BEIJING 100080,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Lee, I,Bai, CL,Wang, C,et al. Computational analysis of triplex formation of oligonucleotides: Protonated and 5-methylated py-pu-py motif[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,1997,40(2):113-121. |
| APA | Lee, I,Bai, CL,Wang, C,&Wang, XW.(1997).Computational analysis of triplex formation of oligonucleotides: Protonated and 5-methylated py-pu-py motif.SCIENCE IN CHINA SERIES B-CHEMISTRY,40(2),113-121. |
| MLA | Lee, I,et al."Computational analysis of triplex formation of oligonucleotides: Protonated and 5-methylated py-pu-py motif".SCIENCE IN CHINA SERIES B-CHEMISTRY 40.2(1997):113-121. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。