Biocompatible [60]/[70] Fullerenols: Potent Defense against Oxidative Injury Induced by Reduplicative Chemotherapy
文献类型：期刊论文
| 作者 | Zhou, Yue1,2; Li, Jie1,2; Ma, Haijun1,2; Zhen, Mingming1,2; Guo, Jun1; Wang, Liping1,2; Jiang, Li1,2; Shu, Chunying1,2; Wang, Chunru1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-10-18 |
| 卷号 | 9期号:41页码:35539-35547 |
| ISSN号 | 1944-8244 |
| 关键词 | Fullerenols Ros Scavenger Cytochrome P-450 Oxidative Injury Chemotherapy Protection |
| DOI | 10.1021/acsami.7b08348 |
| 英文摘要 | Chemotherapy as a conventional cancer treatment suffers from critical systemic side effects, which is generally considered as the consequence of reactive oxygen species (ROS). Fullerenes have been widely studied for their excellent performance in radicals scavenging. In the present study, we report a solid-liquid reaction to synthesize fullerenols and their application as ROS scavengers in chemotherapy protection. The solid-liquid reaction is carried out without catalyst and suitable for mass production. The novel [60]/[70] fulterenols show a high stability in water, and the [70] fullerenols (C-70-OH) exhibit radical scavenging capability superior to that of [60] fullerenols (C-60-OH) in chemotherapy protection. The mouse model for single and reduplicative chemotherapy-induced liver injury dettionstrates their protective effects in the chemotherapeutic process, which is confirmed by histopathological examinations and hematological index. The increase of the hepatic L-glutathione (GSH) level and downregulated,expression of the cytochrome P-450 2E1 (CYP2E1) give the possible mechanism associated with the impact of fullerenols on the metabolism of doxorubicin. The novel fullerenols may be promising protective agents to satisfy the demand for future clinical chemotherapy. |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000413503700005 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/44989]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhen, Mingming; Wang, Chunru |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Mol Nanostruct & Nanotechnol,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yue,Li, Jie,Ma, Haijun,et al. Biocompatible [60]/[70] Fullerenols: Potent Defense against Oxidative Injury Induced by Reduplicative Chemotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(41):35539-35547. |
| APA | Zhou, Yue.,Li, Jie.,Ma, Haijun.,Zhen, Mingming.,Guo, Jun.,...&Wang, Chunru.(2017).Biocompatible [60]/[70] Fullerenols: Potent Defense against Oxidative Injury Induced by Reduplicative Chemotherapy.ACS APPLIED MATERIALS & INTERFACES,9(41),35539-35547. |
| MLA | Zhou, Yue,et al."Biocompatible [60]/[70] Fullerenols: Potent Defense against Oxidative Injury Induced by Reduplicative Chemotherapy".ACS APPLIED MATERIALS & INTERFACES 9.41(2017):35539-35547. |
入库方式： OAI收割
来源：化学研究所
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