Nanoprodrug of retinoic acid-modified paclitaxel
文献类型：期刊论文
| 作者 | Zhou, Zijun1; Yan, Jingzhe1; Sun, Tingting2,3; Wang, Xin4; Xie, Zhigang2 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2017-12-07 |
| 卷号 | 15期号:45页码:9611-9615 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c7ob02553j |
| 英文摘要 | All-trans-retinoic acid (RA) is a non-toxic physiological metabolite of vitamin A. A paclitaxel (PTX) prodrug (RA-PTX) with high PTX content of 75% was synthesized via an easy condensation reaction. RA-PTX nanoparticles (RA-PTX NPs) were prepared through a nanoprecipitation method which increased the water solubility of PTX. RA-PTX NPs were spherical in shape and exhibited favorable structural stability in both water and the physiological environment. RA-PTX NPs possessed effective cellular uptake as revealed by confocal laser scanning microscopy and exerted potent cytotoxicity. These results highlight the potential of nanomedicines from PTX prodrugs for increasing the drug loading and water solubility of PTX. |
| 语种 | 英语 |
| WOS记录号 | WOS:000415990300012 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45003]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Sun, Tingting |
| 作者单位 | 1.Jilin Canc Hosp, 1018 Huguang St, Changchun 130012, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Jilin Univ, Hosp 1, Dept Thyroid Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Zijun,Yan, Jingzhe,Sun, Tingting,et al. Nanoprodrug of retinoic acid-modified paclitaxel[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(45):9611-9615. |
| APA | Zhou, Zijun,Yan, Jingzhe,Sun, Tingting,Wang, Xin,&Xie, Zhigang.(2017).Nanoprodrug of retinoic acid-modified paclitaxel.ORGANIC & BIOMOLECULAR CHEMISTRY,15(45),9611-9615. |
| MLA | Zhou, Zijun,et al."Nanoprodrug of retinoic acid-modified paclitaxel".ORGANIC & BIOMOLECULAR CHEMISTRY 15.45(2017):9611-9615. |
入库方式： OAI收割
来源：化学研究所
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