Temperature-Responsive Hierarchical Polymer Brushes Switching from Bactericidal to Cell Repellency
文献类型：期刊论文
| 作者 | Wang, Xianghong1,3; Yan, Shunjie1; Song, Lingjie1; Shi, Hengchong1; Yang, Huawei1; Luan, Shifang1; Huang, Yubin1; Yin, Jinghua1; Khan, Ather Farooq4; Zhao, Jie2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-11-22 |
| 卷号 | 9期号:46页码:40930-40939 |
| ISSN号 | 1944-8244 |
| 关键词 | Surface-initiated Photoiniferter-mediated Polymerization (Si-pimp) Hierarchical Structure Temperature-responsive Bactericidal Bacterial Repellency |
| DOI | 10.1021/acsami.7b09968 |
| 英文摘要 | Unlike conventional poly(N-isopropylacrylamide) (PNIPAM)-based surfaces switching from bactericidal activity to bacterial repellency upon decreasing temperature, we developed a hierarchical polymer architecture, which could maintain bactericidal activities at room temperature while presenting bacterial repellency at physiological temperature. In this architecture, a thermoresponsive bactericidal upper layer consisting of PNIPAM-based copolymer and vancomycin (Van) moieties was built on an antifouling poly(sulfobetaine methacrylate) (PSBMA) bottom layer via sequential surface-initiated photoiniferter-mediated polymerization. At room temperature below the lower critical solution temperature (LCST), the PNIPAM-based upper layer was stretchable, facilitating contact killing of bacteria by Van. At physiological temperature (above the LOST), the PNIPAM-based layer collapsed, thus leading to the burial of Van and exposure of bottom PSBMA brushes, finally displaying notable performances in bacterial inhibition, dead bacteria detachment, and biocompatibility, simultaneously. Our strategy provides a novel pathway in the rational design of temperature-sensitive switchable surfaces, which shows great advantages in the real-world infection-resistant applications. |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000416614600116 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45015]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Song, Lingjie; Zhao, Jie |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Jilin Univ, Minist Educ, Key Lab Bion Engn, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.COMSATS Inst Informat Technol, Interdisciplinary Res Ctr Biomed Mat, Def Rd,Off Raiwind Rd, Lahore 54000, Pakistan |
| 推荐引用方式 GB/T 7714 | Wang, Xianghong,Yan, Shunjie,Song, Lingjie,et al. Temperature-Responsive Hierarchical Polymer Brushes Switching from Bactericidal to Cell Repellency[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(46):40930-40939. |
| APA | Wang, Xianghong.,Yan, Shunjie.,Song, Lingjie.,Shi, Hengchong.,Yang, Huawei.,...&Zhao, Jie.(2017).Temperature-Responsive Hierarchical Polymer Brushes Switching from Bactericidal to Cell Repellency.ACS APPLIED MATERIALS & INTERFACES,9(46),40930-40939. |
| MLA | Wang, Xianghong,et al."Temperature-Responsive Hierarchical Polymer Brushes Switching from Bactericidal to Cell Repellency".ACS APPLIED MATERIALS & INTERFACES 9.46(2017):40930-40939. |
入库方式： OAI收割
来源：化学研究所
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