A novel bone marrow targeted gadofullerene agent protect against oxidative injury in chemotherapy
文献类型：期刊论文
| 作者 | Zhang, Ying1,2; Shu, Chunying1,2; Zhen, Mingming1,2; Li, Jie1,2; Yu, Tong1,2; Jia, Wang1,2; Li, Xue1,2; Deng, Ruijun1,2; Zhou, Yue1,2; Wang, Chunru1,2 |
| 刊名 | SCIENCE CHINA-MATERIALS
 |
| 出版日期 | 2017-09-01 |
| 卷号 | 60期号:9页码:866-880 |
| ISSN号 | 2095-8226 |
| 关键词 | Gadofullerene Nanocrystals Chemopreventive Agent Myelosuppression Radical Scavenging Chemotherapy Drug |
| DOI | 10.1007/s40843-017-9079-6 |
| 英文摘要 | Chemotherapy as an effective cancer treatment technique has been widely used in tumor therapy. However, it is still a challenge to overcome the serious side effects of chemotherapy, especially for its myelotoxicity. Here we report a novel strategy using the water soluble gadofullerene nano-crystals (GFNCs) to protect against chemotherapy injury in hepatocarcinoma bearing mice, which was induced by the commonly chemotherapeutic agent cyclophosphamide (CTX). The GFNCs were revealed to specifically accumulate in the bone marrow after intravenously injecting to mice and they exhibited excellent radical scavenging function, resulting in a prominent increase of mice blood cells and pathological improvements of the primary organs in the GFNCs (15 mg kg(-1)) treated mice after the CTX (60 mg kg(-1)) therapy. Moreover, the GFNCs maintained and even strengthened the antineoplastic activity of the CTX agent. Therefore, the GFNCs would be the promising chemoprotective agents in chemotherapy based on their high efficiency, low toxicity and metabolizable property. |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000416913800008 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45037]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhen, Mingming; Wang, Chunru |
| 作者单位 | 1.Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ying,Shu, Chunying,Zhen, Mingming,et al. A novel bone marrow targeted gadofullerene agent protect against oxidative injury in chemotherapy[J]. SCIENCE CHINA-MATERIALS,2017,60(9):866-880. |
| APA | Zhang, Ying.,Shu, Chunying.,Zhen, Mingming.,Li, Jie.,Yu, Tong.,...&Wang, Chunru.(2017).A novel bone marrow targeted gadofullerene agent protect against oxidative injury in chemotherapy.SCIENCE CHINA-MATERIALS,60(9),866-880. |
| MLA | Zhang, Ying,et al."A novel bone marrow targeted gadofullerene agent protect against oxidative injury in chemotherapy".SCIENCE CHINA-MATERIALS 60.9(2017):866-880. |
入库方式： OAI收割
来源：化学研究所
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