A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO
文献类型：期刊论文
| 作者 | Gu, Yingchun1,2; Lin, Dayong3; Tang, Yalin1; Fei, Xuening2,3; Wang, Cuihong2; Zhang, Baolian2; Zhou, Jianguo2 |
| 刊名 | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
 |
| 出版日期 | 2018-02-15 |
| 卷号 | 191页码:180-188 |
| 关键词 | Carbazole To Bcl-2 2345 G-quadruplex Targeting Fluorescent Probe Light Up |
| ISSN号 | 1386-1425 |
| DOI | 10.1016/j.saa.2017.10.012 |
| 英文摘要 | As its significant role, the selective recognition of G-quadruplex with specific structures and functions is important in biological and medicinal chemistry. Carbazole derivatives have been reported as a kind of fluorescent probe with many excellent optical properties. In the present study, the fluorescence of the dye (carbazole TO) increased almost 70 fold in the presence of bcl-2 2345 G4 compared to that alone in aqueous buffer condition with almost no fluorescence and 10-30 fold than those in the presence of other DNAs. The binding study results by activity inhibition of G4/Hemin peroxidase experiment, NMR titration and molecular docking simulation showed the high affinity and selectivity to bcl-2 2345 G4 arises from its end-stacking interaction with G-quartet. It is said that a facile approach with excellent sensitive, good selectivity and quick response for bcl-2 2345 G-quadruplex was developed and may be used for antitumor recognition or antitumor agents. (C) 2017 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000418107000021 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45223]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fei, Xuening |
| 作者单位 | 1.Chinese Acad Sci ICCAS, Inst Chem, Beijing 100190, Peoples R China 2.Tianjin Chengjian Univ, Sch Sci, Tianjin 300384, Peoples R China 3.Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Yingchun,Lin, Dayong,Tang, Yalin,et al. A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2018,191:180-188. |
| APA | Gu, Yingchun.,Lin, Dayong.,Tang, Yalin.,Fei, Xuening.,Wang, Cuihong.,...&Zhou, Jianguo.(2018).A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,191,180-188. |
| MLA | Gu, Yingchun,et al."A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO".SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 191(2018):180-188. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。