Recent Advances in the Synthesis of Aryl Nitrile Compounds
文献类型：期刊论文
| 作者 | Yan, Guobing1; Zhang, Yan2,3; Wang, Jianbo2,3 |
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2017-12-11 |
| 卷号 | 359期号:23页码:4068-4105 |
| 关键词 | Arenes Cyanation Nitriles Transition Metal Catalysis |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.201700875 |
| 英文摘要 | Aryl nitriles are widely found in natural products, pharmaceuticals, agrochemicals, dyes, and herbicides. Moreover, because the cyano group can be easily converted into various functional groups, aryl nitriles are important intermediates in synthetic organic chemistry. Consequently, the development of new methodologies for the synthesis of aryl nitriles is of significant interest. The traditional methods for their synthesis include Sandmeyer reactions, Rosenmund-von Braun reactions, as well as dehydration reactions of aldoximes and amides. In recent years, numerous efforts have been devoted to transition metal-catalyzed cyanation reactions of aryl (pseudo)halides, organometallic reagents and aryl C-H bonds. A number of cyanating reagents have been explored for such transformations, including metal cyanides and organic cyano group sources. In addition, styrenes and aryl-substituted alkynes are successfully converted into aryl nitriles through carbon-carbon double or triple bond cleavage. Various benzylic compounds have also been used for the synthesis of aryl nitriles, such as benzylic halides, alcohols, amines and azides. Furthermore, the direct conversion of the methyl group of toluene derivatives into a cyano group has also drawn attention. In this critical review, we summarize the recent developments and useful applications in this field and reaction mechanisms are also briefly discussed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000417648400002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45239]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yan, Guobing; Wang, Jianbo |
| 作者单位 | 1.Lishui Univ, Dept Chem, Lishui 323000, Zhejiang, Peoples R China 2.Peking Univ, Coll Chem, BNLMS, Beijing 100871, Peoples R China 3.Peking Univ, Coll Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Guobing,Zhang, Yan,Wang, Jianbo. Recent Advances in the Synthesis of Aryl Nitrile Compounds[J]. ADVANCED SYNTHESIS & CATALYSIS,2017,359(23):4068-4105. |
| APA | Yan, Guobing,Zhang, Yan,&Wang, Jianbo.(2017).Recent Advances in the Synthesis of Aryl Nitrile Compounds.ADVANCED SYNTHESIS & CATALYSIS,359(23),4068-4105. |
| MLA | Yan, Guobing,et al."Recent Advances in the Synthesis of Aryl Nitrile Compounds".ADVANCED SYNTHESIS & CATALYSIS 359.23(2017):4068-4105. |
入库方式： OAI收割
来源：化学研究所
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