Multi-Targeted Anticancer Agents
文献类型：期刊论文
| 作者 | Zheng, Wei1,2,3; Zhao, Yao1,2,3; Luo, Qun1,2,3,4; Zhang, Yang1,2,3; Wu, Kui1,2,3; Wang, Fuyi1,2,3,4 |
| 刊名 | CURRENT TOPICS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2017 |
| 卷号 | 17期号:28页码:3084-3098 |
| 关键词 | Anticancer Agents Multi-targeting Drug Development Precision Medicine Bcr-abl Cytotoxic Anticancer Drug |
| ISSN号 | 1568-0266 |
| DOI | 10.2174/1568026617666170707124126 |
| 英文摘要 | There is a great demand for the development of novel anticancer drugs, due to the increasing morbidity and high mortality of cancer. To date, chemotherapy still plays a central role in the clinical treatment of cancer, but this role is being reduced by targeted therapies. Since cancer is a complicated and multiple genes involved disease, drugs that act at multiple targets can enhance efficacy and lower drug resistance, and are thought to be the future of novel anticancer drug development. In this paper, we discuss the recent development of "single molecule, multi-target" anticancer agents that combine two or more pharmacophores in a single molecule, including organic multitargeted anticancer agents and metal based complexes such as platinum, ruthenium, iridium and rhodium complexes. These efforts will contribute to clinical cancer therapy and benefit patients in the future. |
| 语种 | 英语 |
| WOS记录号 | WOS:000415882700002 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45309]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, Yao; Wang, Fuyi |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, Natl Ctr Mass Spectrometry Beijing, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Wei,Zhao, Yao,Luo, Qun,et al. Multi-Targeted Anticancer Agents[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2017,17(28):3084-3098. |
| APA | Zheng, Wei,Zhao, Yao,Luo, Qun,Zhang, Yang,Wu, Kui,&Wang, Fuyi.(2017).Multi-Targeted Anticancer Agents.CURRENT TOPICS IN MEDICINAL CHEMISTRY,17(28),3084-3098. |
| MLA | Zheng, Wei,et al."Multi-Targeted Anticancer Agents".CURRENT TOPICS IN MEDICINAL CHEMISTRY 17.28(2017):3084-3098. |
入库方式： OAI收割
来源：化学研究所
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