Development of Integrated Atomic Force Microscopy and Fluorescence Microscopy for Single-Molecule Analysis in Living Cells
文献类型：期刊论文
| 作者 | Qin Ge-Ge1,2; Li Wen-Hui1,2; Xu Jia-Chao1,2; Kou Xiao-Long1,2; Zhao Rong1,2; Luo Fang1,2; Fang Xiao-Hong1,2 |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 45期号:12页码:1813-1822 |
| ISSN号 | 0253-3820 |
| 关键词 | Atomic Force Microscopy Fluorescence Microscopy Single-molecule Fluorescence Imaging Single-molecule Force Spectroscopy Single-molecule Analysis Review |
| DOI | 10.1016/S1872-2040(17)61056-9 |
| 英文摘要 | Atomic force microscope (AFM) and fluorescence microscope (FM) techniques have been emerging as two most commonly used tools for single-molecule study in living cells. Combining the advantages of two microscopes, the development of the integrated AFM-FM technique with high spatiotemporal resolution and multi-function has attracted increasing interest. In this review, the principles of AFM single-molecule force spectroscopy and single-molecule fluorescence imaging are briefly discussed, and the recent advances in the integrated AFM-FM instrumentation are summarized. Subsequently, based on our own research in the investigation of ligand-receptors interactions with the integrated AFM-FM technique, its applications in live-cell single-molecule imaging and characterization are introduced. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000418241000005 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45339]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang Xiao-Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin Ge-Ge,Li Wen-Hui,Xu Jia-Chao,et al. Development of Integrated Atomic Force Microscopy and Fluorescence Microscopy for Single-Molecule Analysis in Living Cells[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2017,45(12):1813-1822. |
| APA | Qin Ge-Ge.,Li Wen-Hui.,Xu Jia-Chao.,Kou Xiao-Long.,Zhao Rong.,...&Fang Xiao-Hong.(2017).Development of Integrated Atomic Force Microscopy and Fluorescence Microscopy for Single-Molecule Analysis in Living Cells.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,45(12),1813-1822. |
| MLA | Qin Ge-Ge,et al."Development of Integrated Atomic Force Microscopy and Fluorescence Microscopy for Single-Molecule Analysis in Living Cells".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 45.12(2017):1813-1822. |
入库方式： OAI收割
来源：化学研究所
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