Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon
文献类型：期刊论文
| 作者 | Su, Fan1; Lu, Yandong1; Kong, Lingran1; Liu, Jingjing2; Luo, Tuoping1,2 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2018-01-15 |
| 卷号 | 57期号:3页码:760-764 |
| 关键词 | Cycloaddition Cyclopropanes Diterpenoids Radical Cyclization Total Synthesis |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201711084 |
| 英文摘要 | A new strategy was devised for the total synthesis of highly oxidized ent-kauranoids. A highly regio- and diastereoselective intermolecular Diels-Alder cycloaddition involving a diene embedded in a substituted bicyclo[4.1.0] skeleton was used to assemble all carbon centers but C17 of the target molecule at an early stage of the synthesis. Subsequent synthetic steps, including redox manipulations, SmI2-mediated cyclization, and isomerization reactions, afforded the antitumor natural product maoecrystal P. |
| 语种 | 英语 |
| WOS记录号 | WOS:000419594700025 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45453]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luo, Tuoping |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China 2.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Fan,Lu, Yandong,Kong, Lingran,et al. Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(3):760-764. |
| APA | Su, Fan,Lu, Yandong,Kong, Lingran,Liu, Jingjing,&Luo, Tuoping.(2018).Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(3),760-764. |
| MLA | Su, Fan,et al."Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.3(2018):760-764. |
入库方式： OAI收割
来源：化学研究所
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