Quantitative single-molecule study of TGF-beta/Smad signaling
文献类型：期刊论文
| 作者 | Zhao, Rong1,2; Li, Nan1,2; Xu, Jiachao1,2; Li, Wenhui1,2; Fang, Xiaohong1,2 |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2018 |
| 卷号 | 50期号:1页码:51-59 |
| 关键词 | Single-molecule Imaging And Tracking Single-molecule Force Spectroscopy Tgf-beta/smad Signaling Pathway Quantitative Analysis |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gmx121 |
| 英文摘要 | TGF-beta/Smad signaling pathway triggers diverse cellular responses among different cell types and environmental conditions. Quantitative analysis of protein-protein interactions involved in TGF-beta/Smad signaling is demanded for understanding the molecular mechanism of this signaling pathway. Live-cell single-molecule microcopy with high spatiotemporal resolution is a new tool to monitor key molecular events in a real-time manner. In this review, we mainly presented the recent work on the quantitative characterization of TGF-beta/Smad signaling proteins by single-molecule method, and showed how it enabled us to obtain new insights about this canonical signaling process. |
| 语种 | 英语 |
| WOS记录号 | WOS:000423304200005 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45485]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang, Xiaohong |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Rong,Li, Nan,Xu, Jiachao,et al. Quantitative single-molecule study of TGF-beta/Smad signaling[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2018,50(1):51-59. |
| APA | Zhao, Rong,Li, Nan,Xu, Jiachao,Li, Wenhui,&Fang, Xiaohong.(2018).Quantitative single-molecule study of TGF-beta/Smad signaling.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,50(1),51-59. |
| MLA | Zhao, Rong,et al."Quantitative single-molecule study of TGF-beta/Smad signaling".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 50.1(2018):51-59. |
入库方式： OAI收割
来源：化学研究所
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