Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment
文献类型：期刊论文
| 作者 | Kuang, Gaizhen1,2; Zhang, Zhiyun2,3; Liu, Shi2; Zhou, Dongfang2; Lu, Xiaolan1; Jing, Xiabin2; Huang, Yubin2 |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 6期号:2页码:324-331 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/c7bm01018d |
| 英文摘要 | The application of the biphasic release profile furnished by electrospun polyblend nanofibers for local cancer treatment was investigated. By adjusting the weight ratio of the hydrophilic polymer (poly(ethylene oxide), PEO) and hydrophobic polymer (poly(L-lactide), PLA), PEO10-PLA90 fibers with typical biphasic release kinetics were successfully prepared. Due to their unique release profile, PEO10-PLA90 fibers can quickly access the tumor site in vivo at a high drug content within 1 h and keep at a high level for longer than two weeks. In vivo antitumor and safety studies demonstrated that PEO10-PLA90 fibers can achieve optimized local cancer treatment efficacy and avoid undesired adverse reactions. The biphasic drug release profile provided by the polyblend electrospun technology was proven to be a new conception for local chemotherapy. |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000423742400008 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45515]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhou, Dongfang; Lu, Xiaolan |
| 作者单位 | 1.Xi An Jiao Tong Univ, Affiliated Hosp 2, Med Sch, Dept Gastroenterol, Xian 710004, Shaanxi, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 3.Northeast Agr Univ, Coll Sci, Harbin 150030, Heilongjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kuang, Gaizhen,Zhang, Zhiyun,Liu, Shi,et al. Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment[J]. BIOMATERIALS SCIENCE,2018,6(2):324-331. |
| APA | Kuang, Gaizhen.,Zhang, Zhiyun.,Liu, Shi.,Zhou, Dongfang.,Lu, Xiaolan.,...&Huang, Yubin.(2018).Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment.BIOMATERIALS SCIENCE,6(2),324-331. |
| MLA | Kuang, Gaizhen,et al."Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment".BIOMATERIALS SCIENCE 6.2(2018):324-331. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。