Self-assembled organic nanorods for dual chemo-photodynamic therapies
文献类型：期刊论文
| 作者 | Li, Yuanyuan1; Hu, Xiuli2; Zheng, Xiaohua3; Liu, Yang4; Liu, Shi2; Yue, Ying1; Xie, Zhigang2 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:10页码:5493-5499 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c8ra00067k |
| 英文摘要 | Photodynamic therapy (PDT) and chemotherapy have been extensively developed as effective approaches against cancer. Herein, we constructed organic nanorods by rational co-assembly of photosensitizer, di-iodinated borondipyrromethene (BDP-I-2), and chemical anticancer drug, paclitaxel (PTX). The physico-and photochemical properties of the obtained nanorods were carefully investigated. BDP-I-2 was selected for its high singlet oxygen (O-1(2)) quantum yields. And the corresponding O-1(2) generation ability and photodynamic effect were evaluated both in vitro and in vivo. The accelerated endosomal escape of the nanorods induced by the photodynamic effect enhanced the chemotherapeutic efficacy of PTX. We believe that this synergetic nanomedicine represents a new development for antitumor chemophotodynamic therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000424024200049 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45549]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Hu, Xiuli; Yue, Ying |
| 作者单位 | 1.Jilin Univ, Hosp 1, Xinmin St, Changchun 130021, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Northeast Normal Univ, Dept Chem, 5268 Renmin St, Changchun 130024, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuanyuan,Hu, Xiuli,Zheng, Xiaohua,et al. Self-assembled organic nanorods for dual chemo-photodynamic therapies[J]. RSC ADVANCES,2018,8(10):5493-5499. |
| APA | Li, Yuanyuan.,Hu, Xiuli.,Zheng, Xiaohua.,Liu, Yang.,Liu, Shi.,...&Xie, Zhigang.(2018).Self-assembled organic nanorods for dual chemo-photodynamic therapies.RSC ADVANCES,8(10),5493-5499. |
| MLA | Li, Yuanyuan,et al."Self-assembled organic nanorods for dual chemo-photodynamic therapies".RSC ADVANCES 8.10(2018):5493-5499. |
入库方式： OAI收割
来源：化学研究所
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