Chitosan-coated cerium oxide nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation
文献类型：期刊论文
| 作者 | Huang, Xue1; Li, Lin-Dong2; Lyu, Guang-Ming2; Shen, Bai-Yu1; Han, Yan-Fei1; Shi, Jing-Lin3; Teng, Jia-Li3; Feng, Li3; Si, Shao-Yan4; Wu, Ji-Hua5 |
| 刊名 | INORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 5期号:2页码:386-393 |
| ISSN号 | 2052-1553 |
| DOI | 10.1039/c7qi00707h |
| 英文摘要 | Inflammation is the initial phase in the healing of cutaneous wounds; however, persistent inflammation will hamper the healing process by generating excess inflammatory cytokines and reactive oxygen species (ROS). Therefore, preventing persistent inflammation and clearing redundant ROS are important strategies in accelerating wound healing. Owing to their unique redox activity, cerium oxide (CeO2) nanoparticles have shown promising potential as antioxidative and anti-inflammatory agents for the treatment of various diseases resulting from oxidative stress. In the present study, we prepared chitosan-coated CeO2 nanocubes (CCNs) and evaluated their cutaneous wound healing potential when topically applied to open excision wounds on adult Sprague Dawley (SD) rats. CCN application significantly increased the wound healing rates and showed superior wound healing capabilities compared to a clinically applied wound healing agent, recombinant human epidermal growth factor (rhEGF). We attribute this superior wound healing ability to their anti-inflammatory ability by decreasing the expression of the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and increasing the expression of the anti-inflammatory cytokine interleukin-10 (IL-10), as well as to their antioxidative ability by increasing antioxidant enzyme levels. These results suggest that CCNs hold therapeutic potential in treating refractory wounds characterized by persistent inflammation caused by oxidative-stress related diseases such as diabetes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000425032100013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45581]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Yan-Jun; Sun, Ling-Dong; Yan, Chun-Hua |
| 作者单位 | 1.Peking Univ, Hosp PLA 306, Dept Endocrinol, Teaching Hosp, Beijing 100101, Peoples R China 2.Peking Univ, State Key Lab Rare Earth Mat Chem & Applicat, Beijing Natl Lab Mol Sci,Coll Chem & Mol Engn, PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Che, Beijing 100871, Peoples R China 3.306 Hosp PLA, Dept Endocrinol, Beijing 100101, Peoples R China 4.306 Hosp PLA, Dept Special Med Res, Beijing 100101, Peoples R China 5.306 Hosp PLA, Dept Pathol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xue,Li, Lin-Dong,Lyu, Guang-Ming,et al. Chitosan-coated cerium oxide nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation[J]. INORGANIC CHEMISTRY FRONTIERS,2018,5(2):386-393. |
| APA | Huang, Xue.,Li, Lin-Dong.,Lyu, Guang-Ming.,Shen, Bai-Yu.,Han, Yan-Fei.,...&Yan, Chun-Hua.(2018).Chitosan-coated cerium oxide nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation.INORGANIC CHEMISTRY FRONTIERS,5(2),386-393. |
| MLA | Huang, Xue,et al."Chitosan-coated cerium oxide nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation".INORGANIC CHEMISTRY FRONTIERS 5.2(2018):386-393. |
入库方式： OAI收割
来源：化学研究所
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