Radiopaque Highly Stiff and Tough Shape Memory Hydrogel Microcoils for Permanent Embolization of Arteries
文献类型：期刊论文
| 作者 | Zhan, Yinyu1; Gao, Haijun2; Wang, Hao2; Xu, Ziyang1; Chen, Xiaowei3; Liu, Bo1; Shi, Yuan2; Lu, Ying4; Wen, Lianfang2; Li, Yan2 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2018-02-28 |
| 卷号 | 28期号:9 |
| 关键词 | Aneurysm Embolization High Modulus High-strength Hydrogels Shape Memory |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201705962 |
| 英文摘要 | Transcatheter arterial embolization of aneurysm with metal microcoils is notoriously prone to recanalization arising from the low filling ratio due to their extreme rigidity. Smart hydrogel microcoils with tunable modulus may essentially significantly improve the therapeutic efficacy. Here, a radiopaque highly stiff body-temperature-triggered shape memory (SM) hydrogel is fabricated for the first time by introducing reversible hydrophobic dipole pairing microdomains in the flexibly crosslinked network, followed by BaSO4 precipitation. This radiopacification does not affect their mechanical performances as well as the SM effect. It is demonstrated that the mechanical properties of SM hydrogels are comparable to those of rubbers and can be modulated by adjusting temperature ranging from 20 to 40 degrees C. Benefiting from the thermoresponsive mechanical properties, the stiff radiopaque hydrogel strip can easily pass through a catheter under the protection of cool saline for delivery into pig's renal artery, and spontaneously and rapidly transformed into a microcoil upon contacting blood. Real-time angiogram reveals that continuous delivery of several hydrogel microcoils can efficiently occlude the blood supply. The kidneys are atrophied considerably over three month postoperative follow-up, and no recanalization occurs throughout the experimental time. These novel hydrogel microcoils are promising to be developed as novel permanent embolic agents for treating aneurysm. |
| 语种 | 英语 |
| WOS记录号 | WOS:000426154500021 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45601]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Feng, Xuequan; Liu, Wenguang |
| 作者单位 | 1.Tianjin Univ, Tianjin Key Lab Composite & Funct Mat, Sch Mat Sci & Engn, Tianjin 300354, Peoples R China 2.Tianjin First Ctr Hosp, Tianjin 300192, Peoples R China 3.Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Natl Synchrotron Radiat Lab, Hefei 230026, Anhui, Peoples R China 4.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhan, Yinyu,Gao, Haijun,Wang, Hao,et al. Radiopaque Highly Stiff and Tough Shape Memory Hydrogel Microcoils for Permanent Embolization of Arteries[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(9). |
| APA | Zhan, Yinyu.,Gao, Haijun.,Wang, Hao.,Xu, Ziyang.,Chen, Xiaowei.,...&Liu, Wenguang.(2018).Radiopaque Highly Stiff and Tough Shape Memory Hydrogel Microcoils for Permanent Embolization of Arteries.ADVANCED FUNCTIONAL MATERIALS,28(9). |
| MLA | Zhan, Yinyu,et al."Radiopaque Highly Stiff and Tough Shape Memory Hydrogel Microcoils for Permanent Embolization of Arteries".ADVANCED FUNCTIONAL MATERIALS 28.9(2018). |
入库方式： OAI收割
来源：化学研究所
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