Near-infrared BODIPY-paclitaxel conjugates assembling organic nanoparticles for chemotherapy and bioimaging
文献类型：期刊论文
| 作者 | Zhang, Tao1; Zhang, Wei2,3; Zheng, Min4; Xie, Zhigang2 |
| 刊名 | JOURNAL OF COLLOID AND INTERFACE SCIENCE
 |
| 出版日期 | 2018-03-15 |
| 卷号 | 514页码:584-591 |
| ISSN号 | 0021-9797 |
| 关键词 | Paclitaxel Bodipy Self-assemble Chemotherapy Near-infrared Imaging |
| DOI | 10.1016/j.jcis.2017.12.074 |
| 英文摘要 | Self-assembly of organic molecules has attracted more and more attention because of precise molecular structure and multifarious synthesis chemistry. Herein, near-infrared brominated borondipyrromethenes (BODIPY) paclitaxel conjugate (BrBDP-2PTX) was synthesized. BrBDP-2PTX could self-assemble into uniform spherical nanoparticles (BrBDP-2PTX NPs) via nanoprecipition method. The obtained nanoparticles showed satisfying stability in aqueous solution and 10% fetal bovine serum (FBS) containing phosphoric acid buffer solution (PBS). Moreover, BrBDP-2PTX NPs could make rapid enzyme response to Proteinase K as evidenced by the obvious changes in size and size distribution. BrBDP-2PTX NPs could be internalized by the HeLa cells and exhibited potent cytotoxicity toward tumor cells (human cervical carcinoma cells and liver hepatocellular carcinoma cells) as revealed by 3-[4,5-dime thylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assays and live/dead staining. Furthermore, in vivo experiments indicated BrBDP-2PTX NPs could be used as efficient bioimaging agents without causing any systemic toxicity. This work highlights the potential of using self-assembly of small organic molecules to develop functional nanomaterials. (C) 2018 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000424963700063 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45611]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Wei; Zheng, Min |
| 作者单位 | 1.Jilin Univ, Dept Gastrointestinal Colorectal & Anal Surg, China Japan Union Hosp, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Changchun Univ Technol, Adv Inst Mat Sci, Sch Chem & Life Sci, 2055 Yannan St, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Tao,Zhang, Wei,Zheng, Min,et al. Near-infrared BODIPY-paclitaxel conjugates assembling organic nanoparticles for chemotherapy and bioimaging[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2018,514:584-591. |
| APA | Zhang, Tao,Zhang, Wei,Zheng, Min,&Xie, Zhigang.(2018).Near-infrared BODIPY-paclitaxel conjugates assembling organic nanoparticles for chemotherapy and bioimaging.JOURNAL OF COLLOID AND INTERFACE SCIENCE,514,584-591. |
| MLA | Zhang, Tao,et al."Near-infrared BODIPY-paclitaxel conjugates assembling organic nanoparticles for chemotherapy and bioimaging".JOURNAL OF COLLOID AND INTERFACE SCIENCE 514(2018):584-591. |
入库方式： OAI收割
来源：化学研究所
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