Conjugated Polymer-Based Photoelectrochemical Cytosensor with Turn-On Enable Signal for Sensitive Cell Detection
文献类型：期刊论文
| 作者 | Liu, Shanshan1,2; He, Ping2; Hussain, Sameer2; Lu, Huan2; Zhou, Xin2; Lv, Fengting2; Liu, Libing2; Dai, Zhihui1; Wang, Shu2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018-02-21 |
| 卷号 | 10期号:7页码:6618-6623 |
| 关键词 | Photoelectrochemical Cytosensor Conjugated Polymers Turn-on Signal Skbr-3 Cell Sensitive Detection |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b18275 |
| 英文摘要 | In this work, a new photoelectrochemical (PEC) cytosensor was constructed by using cationic polyfluorene derivative, poly(9,9-bis(6'-(N,N,N,-trirnethylammonium)hexyl)fluorene-co-alt-1,4-phenylene)bromide (PFP) as the photoelectric-responsive material for sensitive cell detection. Positive-charged PFP with high photoelectric conversion efficiency can generate robust photocurrent under light illumination. In the PEC cytosensor, 3-phosphonopropionic acid was linked to the indium tin oxide electrode, followed by modification with antiepithelial-cell-adhesion-molecule (EpCAM) antibody via amide condensation reaction. Thus, target SKBR-3 cells with overexpressed EpCAM antigen could be captured onto the electrode via the specific antibody antigen interactions. Upon adding cationic PFP, a favorable electrostatic interaction between cationic PFP and negatively charged cell membrane led to a turn-on detection signal for target SKBR-3 cells. This new cytosensor not only exhibits good sensitivity because of the good photoelectric performance of conjugated polymers, but also offers decent selectivity to target cells by taking advantage of the specific antibody antigen recognition. |
| 语种 | 英语 |
| WOS记录号 | WOS:000426143900062 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45687]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Dai, Zhihui; Wang, Shu |
| 作者单位 | 1.Nanjing Normal Univ, Sch Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shanshan,He, Ping,Hussain, Sameer,et al. Conjugated Polymer-Based Photoelectrochemical Cytosensor with Turn-On Enable Signal for Sensitive Cell Detection[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(7):6618-6623. |
| APA | Liu, Shanshan.,He, Ping.,Hussain, Sameer.,Lu, Huan.,Zhou, Xin.,...&Wang, Shu.(2018).Conjugated Polymer-Based Photoelectrochemical Cytosensor with Turn-On Enable Signal for Sensitive Cell Detection.ACS APPLIED MATERIALS & INTERFACES,10(7),6618-6623. |
| MLA | Liu, Shanshan,et al."Conjugated Polymer-Based Photoelectrochemical Cytosensor with Turn-On Enable Signal for Sensitive Cell Detection".ACS APPLIED MATERIALS & INTERFACES 10.7(2018):6618-6623. |
入库方式： OAI收割
来源：化学研究所
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