Dual-Modal Probe Based on Polythiophene Derivative for Pre- and Intraoperative Mapping of Lymph Nodes by SPECT/Optical Imaging
文献类型：期刊论文
| 作者 | Jia, Bing1,2,3; Zhang, Xin1,2; Wang, Bing4; Chen, Muhua1,2; Lv, Fengting4; Wang, Shu4; Wang, Fan1,2,5 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018-02-21 |
| 卷号 | 10期号:7页码:6646-6651 |
| 关键词 | Polythiophene Lymph Nodes Mapping Dual Modality Spect Imaging Optical Imaging |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b01032 |
| 英文摘要 | The metastatic spread of primary tumors to regional lymph nodes (LNs) is an important prognostic indicator for cancer staging and clinical therapy. Therefore, developing lymphatic mapping probes with improved accuracy and efficiency is of vital importance. Conjugated polymers (CPs) have been established as useful optical probes for sensitive biological and chemical detection. As a member of CPs family, polythiophene derivatives have drawn increasing attraction because of their superior photostability, signal amplification ability, and flexible structures for modification. In addition, these excellent properties allow the promising in vivo application to real-time LNs mapping. Here, we first reported a radiolabeled dual-modal probe based on the polythiophene derivative (Tc-99m-PTP) that was used for LNs mapping with high sensitivity and specificity by preoperative single-photon emission computed tomography imaging and intraoperative optical guidance. Tc-99m-PTP exhibits an excellent radio fluorescence guidance ability and a remarkable biocompatibility and holds great potential to be a powerful probe for noninvasive LNs mapping. |
| 语种 | 英语 |
| WOS记录号 | WOS:000426143900065 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45721]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Shu; Wang, Fan |
| 作者单位 | 1.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China 2.Peking Univ, Sch Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China 3.Peking Univ, Hlth Sci Ctr, Med & Hlth Analyt Ctr, Beijing 100191, Peoples R China 4.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Bing,Zhang, Xin,Wang, Bing,et al. Dual-Modal Probe Based on Polythiophene Derivative for Pre- and Intraoperative Mapping of Lymph Nodes by SPECT/Optical Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(7):6646-6651. |
| APA | Jia, Bing.,Zhang, Xin.,Wang, Bing.,Chen, Muhua.,Lv, Fengting.,...&Wang, Fan.(2018).Dual-Modal Probe Based on Polythiophene Derivative for Pre- and Intraoperative Mapping of Lymph Nodes by SPECT/Optical Imaging.ACS APPLIED MATERIALS & INTERFACES,10(7),6646-6651. |
| MLA | Jia, Bing,et al."Dual-Modal Probe Based on Polythiophene Derivative for Pre- and Intraoperative Mapping of Lymph Nodes by SPECT/Optical Imaging".ACS APPLIED MATERIALS & INTERFACES 10.7(2018):6646-6651. |
入库方式： OAI收割
来源：化学研究所
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