Activating TiO2 Nanoparticles: Gallium-68 Serves as a High-Yield Photon Emitter for Cerenkov-Induced Photodynamic Therapy
文献类型：期刊论文
| 作者 | Duan, Dongban1; Liu, Hui1; Xu, Yang1; Han, Yuxiang1; Xu, Mengxin1; Zhang, Zhengchu1; Liu, Zhibo1,2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018-02-14 |
| 卷号 | 10期号:6页码:5278-5286 |
| 关键词 | Cerenkov Radiation Photodynamic Therapy Titanium Dioxide Gallium-68 Positron Emission Tomography |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b17902 |
| 英文摘要 | The classical photodynamic therapy (PDT) requires external light to activate photosensitizers for cancer treatment. However, limited tissue penetration of light has been a long-standing challenge for PDT to cure malignant tumors in deep tissues. Recently, Cerenkov radiation (CR) emitted by radiotracers such as BFfluorodeoxyglucose (18F-FDG) has become an alternative and promising internal light source. Nevertheless, fluorine-18 (F-18) only releases 1.3 photons per decay in average; consequently, injection dose of F-18 goes beyond 10-30 times more than usual to acquire therapeutic efficacy because of its low Cerenkov productivity. Gallium 68 (Ga-68) is a favorable CR source owing to its ready availability from generator and 30-time higher Cerenkov productivity. Herein, we report, for the first time, the use of Ga-68 as a CR source to activate dextran-modified TiO2 nanoparticles (D-TiO2 NPs) for CR-induced PDT. Compared with '8F-FDG, 68Ga-labeled bovine serum albumin (68Ga-BSA) inhibited the growth of 4T1 cells and exhibited significantly stronger DNA damage to tumor cells. In vivo studies showed that the tumor growth was almost completely inhibited when tumor-bearing mice were treated with a combination of D-TiO2 NPs and 68Ga-BSA. This study proved that Ga-68 is a more potent radionuclide for PDT than F-18 both in vitro and in vivo offered a promising strategy of using a diagnostic dose of radioactivity to achieve depth-independent cancer therapy without using any external light source. |
| 语种 | 英语 |
| WOS记录号 | WOS:000425572700015 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45733]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Zhibo |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Radiochem & Radiat Chem Key Lab Fundamental Sci, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Dongban,Liu, Hui,Xu, Yang,et al. Activating TiO2 Nanoparticles: Gallium-68 Serves as a High-Yield Photon Emitter for Cerenkov-Induced Photodynamic Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(6):5278-5286. |
| APA | Duan, Dongban.,Liu, Hui.,Xu, Yang.,Han, Yuxiang.,Xu, Mengxin.,...&Liu, Zhibo.(2018).Activating TiO2 Nanoparticles: Gallium-68 Serves as a High-Yield Photon Emitter for Cerenkov-Induced Photodynamic Therapy.ACS APPLIED MATERIALS & INTERFACES,10(6),5278-5286. |
| MLA | Duan, Dongban,et al."Activating TiO2 Nanoparticles: Gallium-68 Serves as a High-Yield Photon Emitter for Cerenkov-Induced Photodynamic Therapy".ACS APPLIED MATERIALS & INTERFACES 10.6(2018):5278-5286. |
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来源：化学研究所
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