Sulfur speciation defined subcellular localization of coumarin derivatives: Correlation of structural relationship to biological behaviors
文献类型：期刊论文
| 作者 | Yin, Hao-Yan; Tang, Juan; Zhang, Jun-Long |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 29期号:2页码:267-270 |
| ISSN号 | 1001-8417 |
| 关键词 | Fluorescent Imaging Sulfur Speciation Subcellular Localization Sulfonium Mitochondria Targeting Electrostatic Surface Potential |
| DOI | 10.1016/j.cclet.2017.10.007 |
| 英文摘要 | Targeted-delivery is of great importance to molecular probes and drugs for cell biology study. Herein we reported 11 sulfur-containing coumarins as cell imaging probes. Different sulfur speciation of the 4 representative coumarins SC1-SC4 renders them significantly different subcellular localizations and cellular uptake pathways: SC1 containing thioether group located in lysosomes, while sulfoxide and sulfone compounds SC2 and SC3 distributed in the whole cell. Furthermore, the cationic sulfonium containing compound SC4 was internalized by clathrin-mediated endocytosis and localized at mitochondria. By analyzing the molecular parameters of all 11 coumarins, we found that different sulfur speciation affected their lipophilicity and electrostatic surface potential. These two key factors play roles in altering biological behaviors of the coumarins. The results revealed the importance of sulfur speciation on the physicochemical properties and thus subcellular localization of bioprobes. This is useful for designing new functional bioprobes. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000424180600007 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45747]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Jun-Long |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Hao-Yan,Tang, Juan,Zhang, Jun-Long. Sulfur speciation defined subcellular localization of coumarin derivatives: Correlation of structural relationship to biological behaviors[J]. CHINESE CHEMICAL LETTERS,2018,29(2):267-270. |
| APA | Yin, Hao-Yan,Tang, Juan,&Zhang, Jun-Long.(2018).Sulfur speciation defined subcellular localization of coumarin derivatives: Correlation of structural relationship to biological behaviors.CHINESE CHEMICAL LETTERS,29(2),267-270. |
| MLA | Yin, Hao-Yan,et al."Sulfur speciation defined subcellular localization of coumarin derivatives: Correlation of structural relationship to biological behaviors".CHINESE CHEMICAL LETTERS 29.2(2018):267-270. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。