Second Near-Infrared Conjugated Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
文献类型：期刊论文
| 作者 | Sun, Tingting1,2; Dou, Jin-Hu3; Liu, Shi1; Wang, Xin1,4; Zheng, Xiaohua1,2; Wang, Yapei5; Pei, Jian3; Xie, Zhigang1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018-03-07 |
| 卷号 | 10期号:9页码:7919-7926 |
| 关键词 | Conjugated Polymer Second Near-infrared Self-assembly Photoacoustic Imaging Photothermal Therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b01458 |
| 英文摘要 | Photothermal conversion in the second near-infrared (NIR-II) window allows deeper penetration and higher exposure to lasers, but examples of NIR-II photothermal agents are mainly formulated by inorganic compounds. In view of the underlying influence of inorganic materials, a novel NIR-II photothermal nanoagent based on a narrow band gap D-A conjugated polymer (TBDOPV-DT) with 2,2-bithiophene as the donor and thiophene-fused benzodifurandione-based oligo(p-phenylenevinylene) as the acceptor has been developed. More importantly, TBDOPV-DT nanoparticles (TBDOPV-DT NPs) are demonstrated to combine excellent photoacoustic imaging (PM) and photothermal therapy (PTT) ability. TBDOPV-DT NPs exhibit dramatic photostability and heating reproducibility with a photothermal conversion efficiency of 50%. Especially, the NPs possess a remarkable PTT effect toward cancer cells in vitro and can eliminate tumor cells completely in vivo under 1064 nm laser irradiation, while no appreciable side effects have been observed. This study achieves PM-guided cancer therapy |
| 语种 | 英语 |
| WOS记录号 | WOS:000427204100042 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45753]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Pei, Jian; Xie, Zhigang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn,Coll Chem & Mol, Minist Educ,Key Lab Polymer Chem & Phys,Ctr Soft, Beijing 100871, Peoples R China 4.Jilin Univ, Hosp 1, Dept Thyroid Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China 5.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Tingting,Dou, Jin-Hu,Liu, Shi,et al. Second Near-Infrared Conjugated Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(9):7919-7926. |
| APA | Sun, Tingting.,Dou, Jin-Hu.,Liu, Shi.,Wang, Xin.,Zheng, Xiaohua.,...&Xie, Zhigang.(2018).Second Near-Infrared Conjugated Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,10(9),7919-7926. |
| MLA | Sun, Tingting,et al."Second Near-Infrared Conjugated Polymer Nanoparticles for Photoacoustic Imaging and Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 10.9(2018):7919-7926. |
入库方式： OAI收割
来源：化学研究所
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