Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release
文献类型：期刊论文
| 作者 | He, Haozhe1,2; Zhou, Junli2,3; Liu, Yingjie2,3; Liu, Shi2; Xie, Zhigang2; Yu, Meng1; Wang, Yong1; Shuai, Xintao1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018-02-28 |
| 卷号 | 10期号:8页码:7413-7421 |
| 关键词 | Poly(Ether Amine) Morphology Transition Nir-controlled Release Drug Delivery Chemo-photothermal Therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b00194 |
| 英文摘要 | Near-infrared (NIR)-light-controlled drug release has aroused great interest because of its advantages in spatiotemporal control. Herein, a photothermally induced morphology transition of the nanoparticles (NPs) for supersensitive drug release has been demonstrated. Doxorubicin (DOX)- and cyanine (Cy)-coloaded thermosensitive poly(ether amine) NPs (DOX&Cy@PEA81) were developed. Because of the photothermal activity of Cy upon irradiation, increase in temperature at the tumor site results, which would be used not only for photothermal therapy but also to spur the release of DOX from the NPs for tunable chemotherapy. The NIR-laser-driven DOX release was validated by a series of intracellular and in vivo experiments on animals. Meanwhile, the chemo-photothermal combinatorial therapy results in optimal cytotoxicity and tumor inhibition. This article provides a promising approach to realizing supersensitive drug release and synergistic chemo-photothermal therapy for cancer. |
| 语种 | 英语 |
| WOS记录号 | WOS:000426618000070 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45767]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xie, Zhigang; Shuai, Xintao |
| 作者单位 | 1.Sun Yat Sen Univ, PCFM Lab, Minist Educ, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China 2.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Haozhe,Zhou, Junli,Liu, Yingjie,et al. Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(8):7413-7421. |
| APA | He, Haozhe.,Zhou, Junli.,Liu, Yingjie.,Liu, Shi.,Xie, Zhigang.,...&Shuai, Xintao.(2018).Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release.ACS APPLIED MATERIALS & INTERFACES,10(8),7413-7421. |
| MLA | He, Haozhe,et al."Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release".ACS APPLIED MATERIALS & INTERFACES 10.8(2018):7413-7421. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。