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Porous Particle-Reinforced Bioactive Gelatin Scaffold for Large Segmental Bone Defect Repairing

文献类型：期刊论文

作者Cui, Yang1,2; Zhu, Tengjiao3; Li, Ailing1; Liu, Bingchuan4; Cui, Zhiyong4; Qiao, Yan1; Tian, Yun4; Qiu, Dong1,2
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2018-02-28
卷号10期号:8页码:6956-6964
ISSN号1944-8244
关键词Composite Scaffold Bioactivity Gelatin Segmental Bone Defect Bone Regeneration
DOI10.1021/acsami.7b19010
英文摘要Large segmental bone defect repairing remains a big challenge in clinics, and synthetic bone grafts suitable for this purpose are still highly demanded. In this article, hydrophilic composite scaffolds (bioactive hollow particle (BHP) gel scaffold) composed of bioactive hollow nano particles and cross-linked gelatin have been developed. The bioactive nanoparticles have a porous structure as well as high specific surface area; thus, they interact strongly with gelatin to overcome the swelling problem that a hydrophilic polymer scaffold will usually face. With this combination, these BHP gel scaffolds showed porous structure and mechanical properties similar to those of the cancellous bone. They also showed excellent bioactivity and cell growth promotion performance in vitro. The best of them, namely, 10BHP-gel scaffold, was evaluated in vivo on a rat femur model, where it was found that the 5 mm segmental bone defect almost healed with new bone tissue formed in 12 weeks and the scaffold itself degraded at the same time. Thus, 10BHP-gel scaffold may become a potential bone graft for large segmental bone defect healing in the future.
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000426618000020
源URL[http://ir.iccas.ac.cn/handle/121111/45795]  
专题中国科学院化学研究所
通讯作者Tian, Yun; Qiu, Dong
作者单位1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
3.Peking Univ Int Hosp, Dept Orthoped, Beijing 102206, Peoples R China
4.Peking Univ Third Hosp, Dept Orthoped, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Yang,Zhu, Tengjiao,Li, Ailing,et al. Porous Particle-Reinforced Bioactive Gelatin Scaffold for Large Segmental Bone Defect Repairing[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(8):6956-6964.
APA Cui, Yang.,Zhu, Tengjiao.,Li, Ailing.,Liu, Bingchuan.,Cui, Zhiyong.,...&Qiu, Dong.(2018).Porous Particle-Reinforced Bioactive Gelatin Scaffold for Large Segmental Bone Defect Repairing.ACS APPLIED MATERIALS & INTERFACES,10(8),6956-6964.
MLA Cui, Yang,et al."Porous Particle-Reinforced Bioactive Gelatin Scaffold for Large Segmental Bone Defect Repairing".ACS APPLIED MATERIALS & INTERFACES 10.8(2018):6956-6964.

入库方式： OAI收割

来源：化学研究所

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