How G-quadruplex topology and loop sequences affect optical properties of DNA-templated silver nanoclusters
文献类型：期刊论文
| 作者 | Tao, Guangyu; Chen, Yang; Lin, Ruoyun; Zhou, Jiang; Pei, Xiaojing; Liu, Feng; Li, Na |
| 刊名 | NANO RESEARCH
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 11期号:4页码:2237-2247 |
| 关键词 | Silver Nanoclusters G-quadruplex Topology Loop Sequence |
| ISSN号 | 1998-0124 |
| DOI | 10.1007/s12274-017-1844-4 |
| 英文摘要 | In the study of the fabrication of DNA-templated silver nanoclusters (DNA-Ag NCs), how templates affect the fluorescence of the nanoclusters remains unclear, and it has been a challenge to understand the correlation between the properties of the DNA template and the Ag NCs. In this respect, based on the rational design of a series of structurally defined intramolecular G-quadruplexes, we prepared G-quadruplex-templated Ag NCs with a defined G-tetrad-to-silver ratio of 1:2. We evaluated the effect of G-quadruplex topology and loop sequences on the fluorescence of DNA-Ag NCs using circular dichroism, and extinction and emission spectroscopy. G-quadruplex templates with an anti-parallel topology were found to produce Ag NCs with stronger fluorescence compared with parallel and hybrid configurations. Loop bases adjacent to G-tetrads have a more significant impact on the fluorescence of Ag NCs compared with those in the middle of the loop, with adenine largely exhibiting an enhancement effect and thymine being detrimental. Generally, G-quadruplexes having an anti-parallel topology with adenine in the loop adjacent to the G-tetrad would be good templates for producing highly fluorescent Ag NCs. This is the first study to focus on the correlation between G-quadruplex topology/sequence and the optical properties of Ag NCs. We hope that the results of this study will facilitate a more in-depth understanding of correlation between G-quadruplex templates and Ag NCs, and help to understand and utilize their unique attributes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000427907700043 |
| 出版者 | TSINGHUA UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45855]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Na |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing Natl Lab Mol Sci BNLMS,Inst Analyt Chem, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tao, Guangyu,Chen, Yang,Lin, Ruoyun,et al. How G-quadruplex topology and loop sequences affect optical properties of DNA-templated silver nanoclusters[J]. NANO RESEARCH,2018,11(4):2237-2247. |
| APA | Tao, Guangyu.,Chen, Yang.,Lin, Ruoyun.,Zhou, Jiang.,Pei, Xiaojing.,...&Li, Na.(2018).How G-quadruplex topology and loop sequences affect optical properties of DNA-templated silver nanoclusters.NANO RESEARCH,11(4),2237-2247. |
| MLA | Tao, Guangyu,et al."How G-quadruplex topology and loop sequences affect optical properties of DNA-templated silver nanoclusters".NANO RESEARCH 11.4(2018):2237-2247. |
入库方式： OAI收割
来源：化学研究所
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