Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer
文献类型：期刊论文
| 作者 | Jin, Jun1,2,4; Guo, Menyu1,2,4; Liu, Jiaming1,2,4; Liu, Jing1,2,4; Zhou, Huige1,2,4; Li, Jiayang1,2,4; Wang, Liming1,2,4; Liu, Huibiao3,4; Li, Yuliang3,4; Zhao, Yuliang1,2,4 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018-03-14 |
| 卷号 | 10期号:10页码:8436-8442 |
| ISSN号 | 1944-8244 |
| 关键词 | Graphdiyne Doxorubicin Drug Delivery Photothermal Therapy Chemotherapy Combination Treatment |
| DOI | 10.1021/acsami.7b17219 |
| 英文摘要 | Nowadays, two-dimensional (2D) materials have attracted extensive attention as cancer drug delivery platforms owing to their unparalleled physicochemical properties and superior specific surface area. Graphdiyne (GDY) is a novel 2D carbon material. Compared with graphene, GDY not only has benzene rings composed of sp(2)-hybridized carbon atoms but also has acetylene units composed of sp-hybridized carbon atoms; therefore, it possesses multiple conjugated electronic structures. Herein, we used doxorubicin (DOX) as a model drug to develop a GDY nanosheet-based drug delivery platform for a photothermal/chemotherapy combination in living mice. With a high photo thermal conversion ability and drug loading efficiency, GDY/DOX under 808 nm laser irradiation showed a much higher cancer inhibition rate compared with solo therapy both in vitro and in vivo. Furthermore, GDY exhibited great biocompatibility and no obvious side effects, as shown by histopathological examination and serum biochemical analysis. For the first time, our work demonstrated a successful example of GDY for efficient photothermal/chemotherapy and suggests both safety and great promise for GDY in cancer treatment. |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000427910800007 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45869]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Huibiao; Chen, Chunying |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Res Educ Ctr Excellence Mol Sci, CAS Key Lab Organ Solids,Inst Chem, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Jun,Guo, Menyu,Liu, Jiaming,et al. Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(10):8436-8442. |
| APA | Jin, Jun.,Guo, Menyu.,Liu, Jiaming.,Liu, Jing.,Zhou, Huige.,...&Chen, Chunying.(2018).Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer.ACS APPLIED MATERIALS & INTERFACES,10(10),8436-8442. |
| MLA | Jin, Jun,et al."Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer".ACS APPLIED MATERIALS & INTERFACES 10.10(2018):8436-8442. |
入库方式： OAI收割
来源：化学研究所
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