RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin
文献类型：期刊论文
| 作者 | Li, Xue1,2; Zhen, Mingming1,2; Deng, Ruijun1,2; Yu, Tong1,2; Li, Jie1,2; Zhang, Ying1,2; Zou, Toujun1; Zhou, Yue1,2; Lu, Zhigao1,2; Guan, Mirong1,2 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 163页码:142-153 |
| ISSN号 | 0142-9612 |
| 关键词 | Antitumor Agents Gadofullerenes Radiofrequency Tumor Vascular-disruption Ve-cadherin |
| DOI | 10.1016/j.biomaterials.2018.02.028 |
| 英文摘要 | The tumor vasculature with unique characteristics offers an attractive target for anti-cancer therapy. Herein, we put forward a novel antitumor therapeutic mechanism based on the gadofullerene nano crystals (GFNCs), the agent we have previously shown to efficiently disrupt tumor vasculature by size expansion with assistance of radiofrequency (RF). However, the tumor vascular disrupting mechanism of RF-assisted GFNCs treatment was not further studied. In the present work, a rapid tumor blood flow shutdown has been observed by the vascular perfusion imaging in vivo and vascular damages were evident 6 h after the RF-assisted GFNCs treatment. Importantly, a significant down-expression of tumor vascular endothelial cadherin (VE-cadherin) treated by RF-assisted GFNCs was further investigated, which caused vascular collapse, blood flow shut-down and subsequent tumor hemorrhagic necrosis. These findings set forth a systematic mechanism on the superior anti-tumor efficiency by RF-assisted GFNCs treatment. (C) 2018 The Authors. Published by Elsevier Ltd. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000428606700013 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/45985]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhen, Mingming; Wang, Chunru |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Key Lab Mol Nanostruct &, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xue,Zhen, Mingming,Deng, Ruijun,et al. RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin[J]. BIOMATERIALS,2018,163:142-153. |
| APA | Li, Xue.,Zhen, Mingming.,Deng, Ruijun.,Yu, Tong.,Li, Jie.,...&Wang, Chunru.(2018).RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin.BIOMATERIALS,163,142-153. |
| MLA | Li, Xue,et al."RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin".BIOMATERIALS 163(2018):142-153. |
入库方式： OAI收割
来源：化学研究所
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