Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing
文献类型：期刊论文
| 作者 | Guo, Bingyuan1,2,3; Sheng, Yingying1; Zhou, Ke2; Liu, Quansheng2; Liu, Lei2; Wu, Hai-Chen1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2018-03-26 |
| 卷号 | 57期号:14页码:3602-3606 |
| 关键词 | Antibodies Biomarkers Molecular Beacon Nanopore Sensors Quantitative Determination |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201711690 |
| 英文摘要 | A new nanopore sensing strategy based on triplex molecular beacon was developed for the detection of specific DNA or multivalent proteins. The sensor is composed of a triplex-forming molecular beacon and a stem-forming DNA component that is modified with a host-guest complex. Upon target DNA hybridizing with the molecular beacon loop or multivalent proteins binding to the recognition elements on the stem, the DNA probe is released and produces highly characteristic current signals when translocated through -hemolysin. The frequency of current signatures can be used to quantify the concentrations of the target molecules. This sensing approach provides a simple, quick, and modular tool for the detection of specific macromolecules with high sensitivity and excellent selectivity. It may find useful applications in point-of-care diagnostics with a portable nanopore kit in the future. |
| 语种 | 英语 |
| WOS记录号 | WOS:000428350100008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46031]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Lei; Wu, Hai-Chen |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Ctr, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Bingyuan,Sheng, Yingying,Zhou, Ke,et al. Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(14):3602-3606. |
| APA | Guo, Bingyuan,Sheng, Yingying,Zhou, Ke,Liu, Quansheng,Liu, Lei,&Wu, Hai-Chen.(2018).Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(14),3602-3606. |
| MLA | Guo, Bingyuan,et al."Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.14(2018):3602-3606. |
入库方式： OAI收割
来源：化学研究所
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