Novel Engineered Microgels with Amphipathic Network Structures for Simultaneous Tumor and Inflammation Depression
文献类型：期刊论文
| 作者 | Zhou, Xianjing1,2; Qi, Yanxin3; Zhang, Zhijun1; Nie, Jingjing4; Huang, Yubin3; Du, Binyang1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018-03-28 |
| 卷号 | 10期号:12页码:10501-10512 |
| 关键词 | Microgels Amphipathic Network Combination Therapy Inflammation Depression Antitumor Treatment |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b02382 |
| 英文摘要 | Novel engineered microgels with amphipathic network structures were designed and synthesized by copolymerizing N-isopropylacrylamide, 1-vinylimidazole, and 2-(cinnamoyloxy)ethyl methacrylate in the presence of 1,6-dibromohexane. The engineered microgels possess hydrophilic quaternization cross-linking structures and hydrophobic cross-linking inner nanodomains, which are suitable for loading and simultaneous release of hydrophilic nonsteroidal anti-inflammatory drug diclofenac sodium (DS) and hydrophobic antic cancer drug doxorubicin (DOX), respectively. The engineered microgels exhibited excellent stability, low cytotoxicity, and long blood circulation time and could be uptaken into the cytoplasm of cells, metabolized, and excreted from the living body by the kidney and the liver. In vivo experiments showed that with injection of DS and DOX dual-drug-loaded microgels, simultaneous antitumor treatment and inflammation depression were achieved along with high antitumor efficacy and low drug-related toxicity. Such microgels with amphipathic network structures have promising applications for combination therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000428972700070 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46079]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qi, Yanxin; Du, Binyang |
| 作者单位 | 1.Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China 2.Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 4.Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Xianjing,Qi, Yanxin,Zhang, Zhijun,et al. Novel Engineered Microgels with Amphipathic Network Structures for Simultaneous Tumor and Inflammation Depression[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(12):10501-10512. |
| APA | Zhou, Xianjing,Qi, Yanxin,Zhang, Zhijun,Nie, Jingjing,Huang, Yubin,&Du, Binyang.(2018).Novel Engineered Microgels with Amphipathic Network Structures for Simultaneous Tumor and Inflammation Depression.ACS APPLIED MATERIALS & INTERFACES,10(12),10501-10512. |
| MLA | Zhou, Xianjing,et al."Novel Engineered Microgels with Amphipathic Network Structures for Simultaneous Tumor and Inflammation Depression".ACS APPLIED MATERIALS & INTERFACES 10.12(2018):10501-10512. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。