Nanoparticles based on glycyrrhetinic acid modified porphyrin for photodynamic therapy of cancer
文献类型：期刊论文
| 作者 | Wang, Xin1,2; Wang, Peisong1; Xue, Shuai1; Zheng, Xiaohua2,3; Xie, Zhigang2; Chen, Guang1; Sun, Tingting2,3 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2018-03-07 |
| 卷号 | 16期号:9页码:1591-1597 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c7ob03108d |
| 英文摘要 | Self-assembled small molecules, as a novel form of drug presentation, have splendid capabilities for water stability and cell endocytosis. Photodynamic therapy (PDT) is regarded as a promising cancer treatment because it is less invasive and has fewer side effects. In this work, an amphiphilic glycyrrhetinic acid-porphyrin conjugate (TPP-GA) was designed and synthesized, and this could self-assemble into nanoparticles (TPP-GA NPs) in water. The morphology of the TPP-GA NPs was observed using transmission electron microscopy (TEM) and their stability in water was revealed by dynamic light scattering (DLS). The PDT effect of the TPP-GA NPs was confirmed by means of in vitro experiment, after photostability verification. It could be conceived that the application of TPP-GA NPs for PDT is a feasible choice and this work shows progress in the self-assembly of amphiphilic small organic molecules. |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000429266600021 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46107]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Guang; Sun, Tingting |
| 作者单位 | 1.Jilin Univ, Hosp 1, Dept Thyroid Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xin,Wang, Peisong,Xue, Shuai,et al. Nanoparticles based on glycyrrhetinic acid modified porphyrin for photodynamic therapy of cancer[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2018,16(9):1591-1597. |
| APA | Wang, Xin.,Wang, Peisong.,Xue, Shuai.,Zheng, Xiaohua.,Xie, Zhigang.,...&Sun, Tingting.(2018).Nanoparticles based on glycyrrhetinic acid modified porphyrin for photodynamic therapy of cancer.ORGANIC & BIOMOLECULAR CHEMISTRY,16(9),1591-1597. |
| MLA | Wang, Xin,et al."Nanoparticles based on glycyrrhetinic acid modified porphyrin for photodynamic therapy of cancer".ORGANIC & BIOMOLECULAR CHEMISTRY 16.9(2018):1591-1597. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。