Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order
文献类型：期刊论文
| 作者 | Wu, Ming1,2; Zhu, Yutian1; Jiang, Wei1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2018-03-26 |
| 卷号 | 57期号:14页码:3578-3582 |
| 关键词 | Block Copolymers Kinetics Micelles Nanotechnology Self-assembly Release |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201712794 |
| 英文摘要 | Multicompartment micelles (MCPs), comprising sequences of repeated elemental discoid parts connected by fasciculus, were formed by self-assembly of polystyrene-block-poly(2-vinyl pyridine)-block-poly(ethylene oxide). Using an electrostatic field, the MCPs can be disassembled through consequent release of small spherical micelles. During this disassembly process, release of loaded species can be achieved from the micelles in chronological order. Two location-selected cargos (mitoxantrone (MTNT) and fluorescein isothiocyanate (FITC)) in the outer and inner compartments of the micelles can be released in chronological order. Under the applied electrostatic field (intensity: 16kVcm(-1)), the loaded MTNT was rapidly released with more than 80% release, whereas the loaded FITC was slowly released with less than 20% release in 12h. At a later stage (after more than 12h), the loaded MTNT was slowly released with less than 20% release, while the loaded FITC was rapidly released with more than 80% release. |
| 语种 | 英语 |
| WOS记录号 | WOS:000428350100003 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46121]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhu, Yutian; Jiang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Ming,Zhu, Yutian,Jiang, Wei. Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(14):3578-3582. |
| APA | Wu, Ming,Zhu, Yutian,&Jiang, Wei.(2018).Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(14),3578-3582. |
| MLA | Wu, Ming,et al."Disassembly of Multicompartment Polymer Micelles in Spatial Sequence Using an Electrostatic Field and Its Application for Release in Chronological Order".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.14(2018):3578-3582. |
入库方式： OAI收割
来源：化学研究所
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