Development of a fluorescent method for simultaneous measurement of glucose concentrations in interstitial fluid and blood
文献类型：期刊论文
| 作者 | Shi, Ting1,2; Li, Dachao1; Li, Guoqing1; Chen, Limin3; Lin, Yuan3; Xu, Kexin1; Lu, Luo2 |
| 刊名 | MEASUREMENT SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2013-12-01 |
| 卷号 | 24期号:12 |
| 关键词 | Blood Glucose Interstitial Fluid Glucose Delay Fluorescence Competitive Reaction |
| ISSN号 | 0957-0233 |
| DOI | 10.1088/0957-0233/24/12/125701 |
| 英文摘要 | Continuous blood glucose monitoring is of great clinical significance to patients with diabetes. One of the effective methods to monitor blood glucose is to measure glucose concentrations of interstitial fluid (ISF). However, a time-delay problem exists between ISF and blood glucose concentrations, which results in difficulty in indicating real-time blood glucose concentrations. Therefore, we developed a fluorescent method to verify the accuracy and reliability of simultaneous ISF and blood glucose measurement, especially incorporating it into research on the delay relationship between blood and ISF glucose changes. This method is based on a competitive reaction among borate polymer, alizarin and glucose. When glucose molecules combine with borate polymers in alizarin-borate polymer competitively, changes in fluorescence intensity demonstrate changes in glucose concentrations. By applying the measured results to the blood and ISF glucose delay relationship, we were able to calculate the time delay as an average of 2.16 +/- 2.05 min for ISF glucose changes with reference to blood glucose concentrations. |
| 语种 | 英语 |
| WOS记录号 | WOS:000327597700042 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46377]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shi, Ting |
| 作者单位 | 1.Tianjin Univ, State Key Lab Precis Measuring Technol & Instrume, Tianjin 300072, Peoples R China 2.Univ Calif Los Angeles, Sch Med, Dept Med, Torrance, CA 90502 USA 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Ting,Li, Dachao,Li, Guoqing,et al. Development of a fluorescent method for simultaneous measurement of glucose concentrations in interstitial fluid and blood[J]. MEASUREMENT SCIENCE & TECHNOLOGY,2013,24(12). |
| APA | Shi, Ting.,Li, Dachao.,Li, Guoqing.,Chen, Limin.,Lin, Yuan.,...&Lu, Luo.(2013).Development of a fluorescent method for simultaneous measurement of glucose concentrations in interstitial fluid and blood.MEASUREMENT SCIENCE & TECHNOLOGY,24(12). |
| MLA | Shi, Ting,et al."Development of a fluorescent method for simultaneous measurement of glucose concentrations in interstitial fluid and blood".MEASUREMENT SCIENCE & TECHNOLOGY 24.12(2013). |
入库方式： OAI收割
来源：化学研究所
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