Modulation of A beta(1-40) Peptide Fibrillar Architectures by A beta-Based Peptide Amphiphiles
文献类型：期刊论文
| 作者 | He, Chengqian; Han, Yuchun; Zhu, Linyi; Deng, Manli; Wang, Yilin |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2013-09-12 |
| 卷号 | 117期号:36页码:10475-10483 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp4044286 |
| 英文摘要 | Modulation of the fibrillogenesis of amyloid peptide A beta(1-40) with two A beta-based peptide amphiphiles has been studied. Both peptide amphiphiles contain two alkyl chains but in different positions. The two alkyl chains of 2C(12)-A beta(11-17) are attached to the same terminus of A beta(11-17), while those of C-12-A beta(11-17)-C-12 are separately attached to opposite termini of A beta(11-17). Thioflavin T fluorescence spectroscopy shows that all the peptide amphiphiles promote the formation of the cross-beta-sheet structure of A beta(1-40) and the aggregation of A beta(1-40), while 2C(12)-A beta(11-17) does this more efficiently. The atom force microscopy images indicate that the modulations of these two peptide amphiphiles on the A beta(1-40) aggregation experience two distinct pathways. 2C(12)-A beta(11-17) leads to amorphous aggregates, whereas C-12-A beta(11-17)-C-12 generates short rodlike fibrils. However, Fourier transform infrared spectroscopy suggests that the amorphous aggregates and rodlike fibrils display similar secondary structures. This work suggests that the aggregation ability and the aggregate structures of the peptide amphiphiles significantly affect their interactions with A beta(1-40) and lead to different morphologies of the A beta(1-40) aggregates. |
| 语种 | 英语 |
| WOS记录号 | WOS:000330161200012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46417]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Han, Yuchun |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Chengqian,Han, Yuchun,Zhu, Linyi,et al. Modulation of A beta(1-40) Peptide Fibrillar Architectures by A beta-Based Peptide Amphiphiles[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2013,117(36):10475-10483. |
| APA | He, Chengqian,Han, Yuchun,Zhu, Linyi,Deng, Manli,&Wang, Yilin.(2013).Modulation of A beta(1-40) Peptide Fibrillar Architectures by A beta-Based Peptide Amphiphiles.JOURNAL OF PHYSICAL CHEMISTRY B,117(36),10475-10483. |
| MLA | He, Chengqian,et al."Modulation of A beta(1-40) Peptide Fibrillar Architectures by A beta-Based Peptide Amphiphiles".JOURNAL OF PHYSICAL CHEMISTRY B 117.36(2013):10475-10483. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。