Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells
文献类型：期刊论文
| 作者 | Liu, Qiaoling; Zheng, Junpeng; Guan, Mirong; Fang, Xiaohong; Wang, Chunru; Shu, Chunying |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2013-05-22 |
| 卷号 | 5期号:10页码:4328-4333 |
| 关键词 | Carboxyfullerene Oxidative Stress Chemical Structure Cytoprotective Capability C2c12 Cell |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am400535j |
| 英文摘要 | Satellite muscle cells play an important role in regeneration of skeletal muscle. However, they are particularly vulnerable to oxidative stress. Herein, we address our efforts on the cytoprotective activities of carboxyfullerenes with different cage size (C-60 vs C-70) and adduct number on postmitotic muscle cell (C2C12 cell). The correlation of the structural effect on the cytoprotective capability of carboxyfullerenes was evaluated. We find that quadrimalonic acid C-70 fullerene (QF(70)) exhibits higher capability on protecting cells from oxidative-induced stress among these tested carboxyfullerenes. The accumulation of intracellular superoxide dismutase (SOD) is proposed to play an important role in their diverse antioxidative ability. Moreover, the pretreatment of QF(70) could also obviously enhance the viability of myotubes originated from oxidative-stressed C2C12 cells, which facilitates the future application of carboxyfullerenes in tissue engineering and nanomedicine. |
| 语种 | 英语 |
| WOS记录号 | WOS:000319551200047 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46441]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang, Xiaohong |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qiaoling,Zheng, Junpeng,Guan, Mirong,et al. Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(10):4328-4333. |
| APA | Liu, Qiaoling,Zheng, Junpeng,Guan, Mirong,Fang, Xiaohong,Wang, Chunru,&Shu, Chunying.(2013).Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells.ACS APPLIED MATERIALS & INTERFACES,5(10),4328-4333. |
| MLA | Liu, Qiaoling,et al."Protective Effect of C-70-Carboxyfullerene against Oxidative-Induced Stress on Postmitotic Muscle Cells".ACS APPLIED MATERIALS & INTERFACES 5.10(2013):4328-4333. |
入库方式： OAI收割
来源：化学研究所
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